机构：[a]Department of Rehabilitation, Xuanwu Hospital of Capital Medical University, No. 45, Changchun St, Xicheng District, PO Box 100053, Beijing, China康复医学科首都医科大学宣武医院[b]Department of Rehabilitation, Zhongguancun Hospital of Beijing, No. 12, South Zhongguancun Road, Haidian District, Beijing, China[c]Department of Telemedicine, PLA General Hospital, No. 28, Fuxing Road, Haidian District, PO Box 100853, Beijing, China
We investigate the effects of transcranial direct current stimulation (tDCS) on language improvement and cortical activation in nonfluent variant primary progressive aphasia (nfvPPA). A 67-year-old woman diagnosed as nfvPPA received sham-tDCS for 5 days over the left posterior perisylvian region (PPR) in the morning and over left Broca's area in the afternoon in Phases A(1) and A(2), and tDCS for 5 days with an anodal electrode over the left PPR in the morning and over left Broca's area in the afternoon in Phases B-1 and B-2. Auditory word comprehension, picture naming, oral word reading and word repetition subtests of the Psycholinguistic Assessment in Chinese Aphasia (PACA) were administered before and after each phase. The EEG nonlinear index of approximate entropy (ApEn) was calculated before Phase A(1), and after Phases B-1 and B-2. Our findings revealed that the patient improved greatly in the four subtests after A-tDCS and ApEn indices increased in stimulated areas and non-stimulated areas. We demonstrated that anodal tDCS over the left PPR and Broca's area can improve language performance of nfvPPA. tDCS may be used as an alternative therapeutic tool for PPA. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
基金：
three grants from National NaturalScience Foundation of China (Grant Nos. 81171011 and 81272173)
one grant from Science and Technology Projects of Beijing (Grant No. Z121107001012144)
one grant from National Science &Technology Pillar Program (2013BAH14F03)
第一作者机构：[a]Department of Rehabilitation, Xuanwu Hospital of Capital Medical University, No. 45, Changchun St, Xicheng District, PO Box 100053, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[a]Department of Rehabilitation, Xuanwu Hospital of Capital Medical University, No. 45, Changchun St, Xicheng District, PO Box 100053, Beijing, China[c]Department of Telemedicine, PLA General Hospital, No. 28, Fuxing Road, Haidian District, PO Box 100853, Beijing, China
推荐引用方式(GB/T 7714)：
Jie Wang,Dongyu Wu,Yan Chen,et al.Effects of transcranial direct current stimulation on language improvement and cortical activation in nonfluent variant primary progressive aphasia[J].NEUROSCIENCE LETTERS.2013,549:29-33.doi:10.1016/j.neulet.2013.06.019.
APA：
Jie Wang,Dongyu Wu,Yan Chen,Ying Yuan&Meikui Zhang.(2013).Effects of transcranial direct current stimulation on language improvement and cortical activation in nonfluent variant primary progressive aphasia.NEUROSCIENCE LETTERS,549,
MLA：
Jie Wang,et al."Effects of transcranial direct current stimulation on language improvement and cortical activation in nonfluent variant primary progressive aphasia".NEUROSCIENCE LETTERS 549.(2013):29-33
