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Statin therapy does not improve lung function in asthma: A meta-analysis of randomized controlled trials

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机构: [1]Department of Cardiology, Beijing Hospital of the Ministry of Public Health, Beijing, China [2]Department of Cardiology, Xiangya Hospital, Central- South University, Changsha, Hunan Province, China [3]Department of Neurology, Xuanwu Hospital, China Capital Medical University, Beijing, China [4]Department of Internal Medicine, Peking Union Medical College Hospital, Beijing [5]Department of Epidemiology and Evidence-based Medicine, First Affiliated Hospital, China Medical University, Shenyang, Liaoning Province, China
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关键词: Asthma lung function meta-analysis statins

摘要:
Objective: To assess the efficacy of statins in the treatment of asthma. Methods: Electronic databases were searched to identify randomized controlled trials that measured the efficacy of statins in the treatment of asthma, and a meta-analysis of the pooled data was performed. Results: Five trials were identified; four met the inclusion criteria (total number of patients 200). Compared with controls, patients in the statin groups had higher forced expiratory volume in 1 s (FEV1) values before inhaled corticosteroids (0.09 l, 95% confidence interval [CI] -0.06, 0.23), higher FEV1 values after inhaled corticosteroids (0.06 l, 95% CI -0.09, 0.22), and higher morning peak expiratory flow rates (9.87 l, 95% CI -15.66, 35.40). These results were not statistically significant and, furthermore, publication bias was detected. Conclusion: In conclusion, there is currently insufficient evidence to show that statins improve lung function in patients with asthma.

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出版当年[2012]版:
大类 | 4 区 医学
小类 | 4 区 医学:研究与实验 4 区 药学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 医学:研究与实验 4 区 药学
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出版当年[2011]版:
Q4 PHARMACOLOGY & PHARMACY Q4 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版:
Q4 MEDICINE, RESEARCH & EXPERIMENTAL Q4 PHARMACOLOGY & PHARMACY

影响因子: 最新[2023版] 最新五年平均 出版当年[2011版] 出版当年五年平均 出版前一年[2010版] 出版后一年[2012版]

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第一作者机构: [1]Department of Cardiology, Beijing Hospital of the Ministry of Public Health, Beijing, China
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通讯机构: [*1]Department of Epidemiology and Evidence-based Medicine, First Affiliated Hospital, China Medical University, 155 Nanjing North Street, Heping District, Shenyang 110001, Liaoning Province, China.
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