机构:[1]Department of Cardiology, Beijing Hospital of the Ministry of Public Health, Beijing, China[2]Department of Cardiology, Xiangya Hospital, Central- South University, Changsha, Hunan Province, China[3]Department of Neurology, Xuanwu Hospital, China Capital Medical University, Beijing, China神经内科首都医科大学宣武医院[4]Department of Internal Medicine, Peking Union Medical College Hospital, Beijing[5]Department of Epidemiology and Evidence-based Medicine, First Affiliated Hospital, China Medical University, Shenyang, Liaoning Province, China
Objective: To assess the efficacy of statins in the treatment of asthma. Methods: Electronic databases were searched to identify randomized controlled trials that measured the efficacy of statins in the treatment of asthma, and a meta-analysis of the pooled data was performed. Results: Five trials were identified; four met the inclusion criteria (total number of patients 200). Compared with controls, patients in the statin groups had higher forced expiratory volume in 1 s (FEV1) values before inhaled corticosteroids (0.09 l, 95% confidence interval [CI] -0.06, 0.23), higher FEV1 values after inhaled corticosteroids (0.06 l, 95% CI -0.09, 0.22), and higher morning peak expiratory flow rates (9.87 l, 95% CI -15.66, 35.40). These results were not statistically significant and, furthermore, publication bias was detected. Conclusion: In conclusion, there is currently insufficient evidence to show that statins improve lung function in patients with asthma.
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外文
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PubmedID:
中科院(CAS)分区:
出版当年[2012]版:
大类|4 区医学
小类|4 区医学:研究与实验4 区药学
最新[2023]版:
大类|4 区医学
小类|4 区医学:研究与实验4 区药学
JCR分区:
出版当年[2011]版:
Q4PHARMACOLOGY & PHARMACYQ4MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版:
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
第一作者机构:[1]Department of Cardiology, Beijing Hospital of the Ministry of Public Health, Beijing, China
通讯作者:
通讯机构:[*1]Department of Epidemiology and Evidence-based Medicine, First Affiliated Hospital, China Medical University, 155 Nanjing North Street, Heping District, Shenyang 110001, Liaoning Province, China.
推荐引用方式(GB/T 7714):
Xiao-bei Si,Shuo Zhang,Lin-yu Huo,et al.Statin therapy does not improve lung function in asthma: A meta-analysis of randomized controlled trials[J].JOURNAL OF INTERNATIONAL MEDICAL RESEARCH.2013,41(2):276-283.doi:10.1177/0300060513477005.
APA:
Xiao-bei Si,Shuo Zhang,Lin-yu Huo,Wen-li Dai&Hai-long Wang.(2013).Statin therapy does not improve lung function in asthma: A meta-analysis of randomized controlled trials.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,41,(2)
MLA:
Xiao-bei Si,et al."Statin therapy does not improve lung function in asthma: A meta-analysis of randomized controlled trials".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 41..2(2013):276-283