机构：[a]Department of Neurology, Xuanwu Hospital, Beijing, China神经内科首都医科大学宣武医院[b]Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China[c]First Affiliated Hospital, Medical College of Shantou University, Shantou, Guangdong, China[d]School of Basic Courses, Baotou Medical College, Baotou, Neimenggu, China[e]Graduate School of Peking Union Medicine College, China Graduate School of Peking Union Medicine College, Beijing, China[f]Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China[g]College of Life Sciences, Peking University, Beijing, China[h]Department of Cardiology, Chaoyang Hospital, Beijing, China
KCNK17 (potassium channel, subfamily K, member17) was first discovered to associate with the pathogenesis of ischemic stroke in the first genome-wide association study. The rs10947803 SNP in KCNK17 is significantly associated with ischemic stroke in Caucasian populations. The aim of the present study was to investigate the association with strokes in the Chinese population. A total of 1364 stroke patients and 1293 controls were examined using a case-control methodology. The rs10947803 SNP in KCNK17 was genotyped by a TaqMan real-time PCR assay. The rs10947803 SNP (A allele) of KCNK17 was significantly associated with cerebral hemorrhage (for AA+AC versus CC, unadjusted odds ratio [OR]=1.70; 95% confidence interval [CI], 1.08-2.69; P=0.020). After adjustment for age and sex, the association remained significant for AA+AC versus CC, OR=1.65; 95% CI, 1.04-2.62; P=0.033. In addition, the rs10947803 SNP in KCNK17 was not associated with ischemic stroke (for AA+AC versus CC, unadjusted OR=0.92; 95% CI, 0.81-1.05; P=0.212, after age- and sex-adjustment, OR=0.87; 95% CI, 0.72-1.05; P=0.143).The rs10947803 SNP (A allele) in KCNK17 increases the risk of cerebral hemorrhage but not ischemic stroke in the Chinese population. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
基金：
the Beijing Hypertension League Institute
F. Hoffmann-La Roche and the National Infrastructure Program of Chinese Genetic Resources (2005DKA21300)
第一作者机构：[a]Department of Neurology, Xuanwu Hospital, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[*1]First Affiliated Hospital, Medical College of Shantou University, Shantou, Guangdong 515041, China.[*2]Department of Cardiology, Chaoyang Hospital, Capital Medical University, 8th Gongtinanlu Road, Beijing 100020, China.[*3]Laboratory of Human Genetics, Beijing Hypertension League Institute, 24 Shijingshan Road, Beijing 100043, China.
推荐引用方式(GB/T 7714)：
Qingfeng Ma,Yongqin Wang,Yue Shen,et al.The rs10947803 SNP of KCNK17 is associated with cerebral hemorrhage but not ischemic stroke in a Chinese population[J].NEUROSCIENCE LETTERS.2013,539:82-85.doi:10.1016/j.neulet.2013.01.041.
APA：
Qingfeng Ma,Yongqin Wang,Yue Shen,Xin Liu,Xiaotong Zhu...&Xingyu Wang.(2013).The rs10947803 SNP of KCNK17 is associated with cerebral hemorrhage but not ischemic stroke in a Chinese population.NEUROSCIENCE LETTERS,539,
MLA：
Qingfeng Ma,et al."The rs10947803 SNP of KCNK17 is associated with cerebral hemorrhage but not ischemic stroke in a Chinese population".NEUROSCIENCE LETTERS 539.(2013):82-85
