机构：[1]Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA[2]Harvard University, Center for Brain Science, Cambridge, MA 02138, USA[3]Ludwig Maximilians University Munich, Institute of Clinical Radiology, Munich 81377, Germany[4]Department of Neurology, Massachusetts General Hospital, Brigham and Women’s Hospital, Boston, MA 02114, USA[5]Neuroscience and Behavioral Disorders Program, Duke-NUS Graduate Medical School, Singapore 169857, Singapore[6]Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA[7]Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China放射科首都医科大学宣武医院
The fact that people think or behave differently from one another is rooted in individual differences in brain anatomy and connectivity. Here, we used repeated-measurement resting-state functional MRI to explore intersubject variability in connectivity. Individual differences in functional connectivity were heterogeneous across the cortex, with significantly higher variability in heteromodal association cortex and lower variability in unimodal cortices. Intersubject variability in connectivity was significantly correlated with the degree of evolutionary cortical expansion, suggesting a potential evolutionary root of functional variability. The connectivity variability was also related to variability in sulcal depth but not cortical thickness, positively correlated with the degree of long-range connectivity but negatively correlated with local connectivity. A meta-analysis further revealed that regions predicting individual differences in cognitive domains are predominantly located in regions of high connectivity variability. Our findings have potential implications for understanding brain evolution and development, guiding intervention, and interpreting statistical maps in neuroimaging.
基金：
NINDS grant (K25NS069805)
the German Research Foundation (MU 3222/2-1)
第一作者机构：[1]Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA[2]Harvard University, Center for Brain Science, Cambridge, MA 02138, USA[3]Ludwig Maximilians University Munich, Institute of Clinical Radiology, Munich 81377, Germany
通讯作者：
通讯机构：[1]Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
推荐引用方式(GB/T 7714)：
Sophia Mueller,Danhong Wang,Michael D. Fox,et al.Individual Variability in Functional Connectivity Architecture of the Human Brain[J].NEURON.2013,77(3):586-595.doi:10.1016/j.neuron.2012.12.028.
APA：
Sophia Mueller,Danhong Wang,Michael D. Fox,B.T. Thomas Yeo,Jorge Sepulcre...&Hesheng Liu.(2013).Individual Variability in Functional Connectivity Architecture of the Human Brain.NEURON,77,(3)
MLA：
Sophia Mueller,et al."Individual Variability in Functional Connectivity Architecture of the Human Brain".NEURON 77..3(2013):586-595
医学