机构：[1]Translational Neuroimaging Laboratory, Douglas Hospital, McGill University, Montreal, Quebec, Canada,[2]McGill Centre for Studies in Aging, McGill University, Montreal, Quebec, Canada,[3]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China,神经内科首都医科大学宣武医院[4]McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
Background: The hypothetical model of dynamic biomarkers for Alzheimer's disease (AD) describes high amyloid deposition and hypometabolism at the mild cognitive impairment (MCI) stage. However, it remains unknown whether brain amyloidosis and hypometabolism follow the same trajectories in MCI individuals. We used the concept of early MCI (EMCI) and late MCI (LMCI) as defined by the Alzheimer's disease Neuroimaging Initiative (ADNI)-Go in order to compare the biomarker profile between EMCI and LMCI. Objectives: To examine the global and voxel-based neocortical amyloid burden and metabolism among individuals who are cognitively normal (CN), as well as those with EMCI, LMCI and mild AD. Methods: In the present study, 354 participants, including CN (n = 109), EMCI (n = 157), LMCI (n = 39) and AD (n = 49), were enrolled between September 2009 and November 2011 through ADNI-GO and ADNI-2. Brain amyloid load and metabolism were estimated using [F-18]AV45 and [F-18] fluorodeoxyglucose ([F-18]FDG) PET, respectively. Uptake ratio images of [F-18]AV45 and [F-18]FDG were calculated by dividing the summed PET image by the median counts of the grey matter of the cerebellum and pons, respectively. Group differences of global [F-18]AV45 and [F-18]FDG were analyzed using ANOVA, while the voxel-based group differences were estimated using statistic parametric mapping (SPM). Results: EMCI patients showed higher global [F-18]AV45 retention compared to CN and lower uptake compared to LMCI. SPM detected higher [F-18] AV45 uptake in EMCI compared to CN in the precuneus, posterior cingulate, medial and dorsal lateral prefrontal cortices, bilaterally. EMCI showed lower [F-18]AV45 retention than LMCI in the superior temporal, inferior parietal, as well as dorsal lateral prefrontal cortices, bilaterally. Regarding to the global [F-18] FDG, EMCI patients showed no significant difference from CN and a higher uptake ratio compared to LMCI. At the voxel level, EMCI showed higher metabolism in precuneus, hippocampus, entorhinal and inferior parietal cortices, as compared to LMCI. Conclusions: The present results indicate that brain metabolism remains normal despite the presence of significant amyloid accumulation in EMCI. These results suggest a role for anti-amyloid interventions in EMCI aiming to delay or halt the deposition of amyloid and related metabolism impairment.
基金：
Canadian institutes of Health Research (CIHR) (MOP-11-51-31)
Alzheimer’s Association(NIRG-08-92090)
National Nature Science Foundation of China (NSFC) (3070024)
Beijing Scientific and Technological New Star Program (2007B069)
Nussia & Andre′ Aisenstadt Foundation
Fonds de la recherche en sante′ du Que′bec. Data collection
the Alzheimer’s Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904)
第一作者机构：[1]Translational Neuroimaging Laboratory, Douglas Hospital, McGill University, Montreal, Quebec, Canada,[2]McGill Centre for Studies in Aging, McGill University, Montreal, Quebec, Canada,[3]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China,
通讯作者：
通讯机构：[1]Translational Neuroimaging Laboratory, Douglas Hospital, McGill University, Montreal, Quebec, Canada,[4]McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
推荐引用方式(GB/T 7714)：
Liyong Wu,Jared Rowley,Sara Mohades,et al.Dissociation between Brain Amyloid Deposition and Metabolism in Early Mild Cognitive Impairment[J].PLOS ONE.2012,7(10):doi:10.1371/journal.pone.0047905.
APA：
Liyong Wu,Jared Rowley,Sara Mohades,Antoine Leuzy,Marina Tedeschi Dauar...&Pedro Rosa-Neto.(2012).Dissociation between Brain Amyloid Deposition and Metabolism in Early Mild Cognitive Impairment.PLOS ONE,7,(10)
MLA：
Liyong Wu,et al."Dissociation between Brain Amyloid Deposition and Metabolism in Early Mild Cognitive Impairment".PLOS ONE 7..10(2012)
