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Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease

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机构: [1]State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. [2]National Human Genome Center at Beijing, Beijing, China. [3]Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China. [4]National Engineering Research Center for Beijing Biochip Technology (NERCBBT), Beijing, China. [5]Medical Systems Biology Research Center, School of Medicine, Tsinghua University, Beijing, China. [6]Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri, USA. [7]Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China. [8]Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumchi, China. [9]Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China. [10]Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China. [11]Cardio-Cerebrovascular Control and Research Center, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, China. [12]Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China. [13]Department of Cardiology, Fujian Provincial People’s Hospital, Fuzhou, China. [14]Department of Epidemiology and Social Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China. [15]Department of Cardiology, The Affiliated Hospital of Beihua University, Beihua University, Jilin, China. [16]Department of Cardiology, First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an, China. [17]Center for Chronic and Noncommunicable Disease Control and Prevention, Sichuan Center of Disease Control and Prevention, Chengdu, China. [18]Cardiovascular Disease Prevention Center, Shougang Hospital, Peking University, Beijing, China. [19]Department of Cardiology, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. [20]School of Public Health, Hebei United University, Tangshan, China. [21]Department of Cardiology, Anzhen Hospital, Capital Medical University, Beijing, China. [22]Department of Emergency Medicine, Beijing Jishuitan Hospital, Beijing, China. [23]School of Public Health, Zhengzhou University, Zhengzhou, China. [24]School of Medicine, Shenzhen University, Shenzhen, China. [25]Department of Internal Medicine, Xinle Red Cross Hospital, Xinle, China. [26]Department of Internal Medicine, Yuxian Renmin Hospital, Yuxian, China. [27]Institute of Geriatrics, Chinese People’s Liberation Army (PLA) General Hospital, Beijing, China. [28]Renqiu Heath Bureau, Renqiu, China. [29]Nantong Center of Disease Control and Prevention, Nantong, China. [30]Zhangqiu Heath Bureau, Zhangqiu, China. [31]Xin’an Heath Bureau, Xin’an, China. [32]Department of Internal Medicine, Shijiazhuang Greatwall Hospital, Shijiazhuang, China. [33]Department of Cardiology, Hanzhong Renmin Hospital, Hanzhong, China. [34]Medizinische Klinik II, Universit?t zu Lübeck, Lübeck, Germany. [35]Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Universit?t zu Lübeck, Lübeck, Germany. [36]Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK. [37]Leicester National Institute for Health Research, Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, UK. [38]Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA. [39]Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA. [40]Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [41]The Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA. [42]A full list of members and affiliations is provided in the Supplementary Note. [43]Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. [44]Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
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We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 x 10(-8)). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (in or near PHACTR1, TCF21, CDKN2A-CDKN2B and C12orf51). These findings provide new insights into pathways contributing to the susceptibility for coronary artery disease in the Chinese Han population.

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基金编号: 2011CB503901 2006CB503805 30930047 2009AA022703 2012AA02A516 2006AA02A406 2006BAI01A01 H020220030130

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出版当年[2011]版:
大类 | 1 区 生物
小类 | 1 区 遗传学
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大类 | 1 区 生物学
小类 | 1 区 遗传学
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Q1 GENETICS & HEREDITY
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Q1 GENETICS & HEREDITY

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第一作者:
第一作者机构: [1]State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. [2]National Human Genome Center at Beijing, Beijing, China.
通讯机构: [1]State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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