机构：[a]Department of Radiology, Meitan General Hospital, Beijing, China 100028[b]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China 100053放射科首都医科大学宣武医院[c]The International WIC Institute, Beijing University of Technology, China 100124[d]Department of Life Science and Informatics, Maebashi Institute of Technology, Japan 3710816[e]The heart center, Meitan General Hospital, Beijing, China 100028
Purpose: To explore the blood oxygen level dependent (BOLD) response in the posterior cingulate cortex (PCC) and the adjacent precuneus regions in healthy elderly adults during problem solving tasks. Materials and Methods: Eighteen participants (7 women, mean age of 63.6 +/- 6.0 years old) were analyzed. The functional magnetic resonance imaging (fMRI) tasks were simplified 4 x 4 Sudoku puzzles that were divided into simple tasks (using the row rule or the column rule to solve the puzzle) and complex tasks (using both the row and column rules to solve the puzzle). Results: The mean accuracy on the simple task was higher than that on the complex task (P = 0.04); the reaction time on the simple task was shorter than that on the complex task (P = 0.001). On both tasks, the participants showed deactivation in the bilateral PCC/precuneus regions. The extent of deactivation on the complex task was greater than that on the simple task (left: P = 0.04; right: P = 0.04). Conclusions: Healthy elderly adults showed deactivation in the bilateral PCC and precuneus regions during a problem solving task; in addition, the extent of deactivation was enhanced by increasing the difficulty of the problem solving task. (C) 2012 Elsevier B.V. All rights reserved.
基金：
the National Natural Science Foundation of China (under Grant No.60875075 as well as No.81000606)
第一作者机构：[a]Department of Radiology, Meitan General Hospital, Beijing, China 100028[b]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China 100053[*2]Department of Radiology, Meitan General Hospital, 29# Xibahe Nanli, Chaoyang District, Beijing, China 100028
通讯作者：
通讯机构：[*1]Department of Radiology, Xuanwu Hospital, Capital Medical University, 45# Changchun Street, Xuanwu District, Beijing, China 100053.[*2]Department of Radiology, Meitan General Hospital, 29# Xibahe Nanli, Chaoyang District, Beijing, China 100028[*3]The International WIC Institute, Beijing University of Technology, China 100124.
推荐引用方式(GB/T 7714)：
Guangwei Jin,Kuncheng Li,Yulin Qin,et al.fMRI study in posterior cingulate and adjacent precuneus cortex in healthy elderly adults using problem solving task[J].JOURNAL OF THE NEUROLOGICAL SCIENCES.2012,318(1-2):135-139.doi:10.1016/j.jns.2012.02.032.
APA：
Guangwei Jin,Kuncheng Li,Yulin Qin,Ning Zhong,Haiyan Zhou...&Qingyu Zeng.(2012).fMRI study in posterior cingulate and adjacent precuneus cortex in healthy elderly adults using problem solving task.JOURNAL OF THE NEUROLOGICAL SCIENCES,318,(1-2)
MLA：
Guangwei Jin,et al."fMRI study in posterior cingulate and adjacent precuneus cortex in healthy elderly adults using problem solving task".JOURNAL OF THE NEUROLOGICAL SCIENCES 318..1-2(2012):135-139
