机构:[1]Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing 100053, China老年医学科首都医科大学宣武医院[2]Department of Pharmacology, Institute of Basic Medical Sciences, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100005, China
Our previous research showed that octacosanol exerted its protective effects in 6-hydroxydopamine-induced Parkinsonian rats. The goal of this study was to investigate whether octacosanol would attenuate neurotoxicity in 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP)-treated C57BL/6N mice and its potential mechanism. Behavioral tests, tyrosine hydroxylase immunohistochemistry and western blot were used to investigate the effects of octacosanol in a mouse model of Parkinson's disease. Oral administration of octacosanol (100 mg/kg) significantly improved behavioral impairments in mice treated by MPTP and markedly ameliorated morphological appearances of tyrosine hydroxylase-positive neuronal cells in the substantia nigra. Furthermore, octacosanol blocked MPTP-induced phosphorylation of p38MAPK and JNK, but not ERK1/2. These findings implicated that the protective effects afforded by octacosanol might be mediated by blocking the phosphorylation of p38MAPK and JNK on the signal transduction in vivo. Considering its excellent tolerability, octacosanol might be considered as a candidate agent for clinical application in treating Parkinson's disease.
基金:
National Basic Research Program of China (973 Program)(No.2007B507400, 2010CB934002, 2011CB504101,2011CBA00408)
the National Natural Science Foundation of China( No. 81050025)
the grant from the Ministry of Science and Technology of China Eleventh 5-year
Plan-Technical Platform for Drug Development(No.2009ZX09303-8)
第一作者机构:[1]Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
通讯作者:
通讯机构:[*1]Department of Pharmacology, Institute of Basic Medical Sciences, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100005, China[*2]Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
推荐引用方式(GB/T 7714):
Tao Wang,Yanyong Liu,Nan Yang,et al.Anti-parkinsonian effects of octacosanol in 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-treated mice[J].NEURAL REGENERATION RESEARCH.2012,7(14):1080-1087.doi:10.3969/j.issn.1673-5374.2012.14.006.
APA:
Tao Wang,Yanyong Liu,Nan Yang,Chao Ji,Piu Chan&Pingping Zuo.(2012).Anti-parkinsonian effects of octacosanol in 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-treated mice.NEURAL REGENERATION RESEARCH,7,(14)
MLA:
Tao Wang,et al."Anti-parkinsonian effects of octacosanol in 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-treated mice".NEURAL REGENERATION RESEARCH 7..14(2012):1080-1087