机构：[1]Xuan Wu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院[2]Beijing Tongren Hospital, Capital Medical University, Beijing, China[3]Beijing Chaoyang Hospital, Capital Medical University, Beijing,China.
Early-onset familial Alzheimer’s disease (EOFAD) is a rare
but important type of Alzheimer’s disease (AD). Asymptomatic carriers of EOFAD gene mutations harbor AD neuropathological features and are prone to develop dementia.
Due to its high penetrance, neurochemistry and predictable
natural history EOFAD is the ideal population for assessing
the evolution of AD. Although 228 mutations have been
already described for presenilin 1 (PS1), presenilin 2 (PS2)
and amyloid presursor protein (APP) genes, EOFAD constitute an important population for research on the genetic
basis of AD since nearly half of kindreds remains without
molecular diagnosis.
第一作者机构：[1]Xuan Wu Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Xuan Wu Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Jianping Jia,E. H. Xu,B. Y. Fang,et al.CHINESE EARLY-ONSET FAMILIAL ALZHEIMER'S DISEASE[J].NEUROBIOLOGY OF AGING.2012,33:s17.doi:10.1016/j.neurobiolaging.2012.01.056.
APA：
Jianping Jia,E. H. Xu,B. Y. Fang,W. Qin,L. F. Jia&Y. Wang.(2012).CHINESE EARLY-ONSET FAMILIAL ALZHEIMER'S DISEASE.NEUROBIOLOGY OF AGING,33,
MLA：
Jianping Jia,et al."CHINESE EARLY-ONSET FAMILIAL ALZHEIMER'S DISEASE".NEUROBIOLOGY OF AGING 33.(2012):s17
