Carbonic Anhydrases III and IV Autoantibodies in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Diabetes, Hypertensive Renal Disease, and Heart Failure
机构：[1]Department of Clinical Laboratory, Xuanwu Hospital, Capital Medical University, 45 Changchun Road, Beijing 100053, China检验科首都医科大学宣武医院[2]Department of Oncology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China[3]Department of Clinical Immune, Xiangya School of Medicine, Central South University, Changsha 410078, Hunan, China
In the present study, the CA III and IV autoantibodies, CA activity, antioxidant enzymes and cytokines in rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), diabetes, hypertensive renal disease, and heart failure were investigated. The anti-CA III antibody titers in patients with RA, SLE, and type 1 diabetes (T1D) were significantly higher than that in control groups (P < 0.05). The anti-CA IV antibody titers in patients with RA, SLE, type 1 diabetic nephropathy (T1DN), and heart failure were significantly higher than that in control groups (P < 0.05) while anti-CA IV antibody could suppress the total CA activity. The SOD and GPx levels in patients with RA, SLE, and T1DN were significantly lower than that in control groups (P < 0.05). IL-6, IL-17, IFN-gamma, and TNF-alpha levels were significantly higher in SLE group compared with the control group (P < 0.05). Weak but significant correlations were found between anti-CA III antibodies and ESR in RA (r = 0.403, P = 0.013) and SLE patients (r = 0.397, P = 0.007). These results suggested that the generation of CA III and IV autoantibodies, antioxidant enzymes, and cytokines might influence each other and CA autoantibodies might affect the normal physiology function of CA.
基金：
Natural Science Foundation of China (No. 81271924)
第一作者机构：[1]Department of Clinical Laboratory, Xuanwu Hospital, Capital Medical University, 45 Changchun Road, Beijing 100053, China
通讯作者：
通讯机构：[1]Department of Clinical Laboratory, Xuanwu Hospital, Capital Medical University, 45 Changchun Road, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Chengeng Liu,YueWei,JianminWang,et al.Carbonic Anhydrases III and IV Autoantibodies in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Diabetes, Hypertensive Renal Disease, and Heart Failure[J].CLINICAL & DEVELOPMENTAL IMMUNOLOGY.2012,2012:doi:10.1155/2012/354594.
APA：
Chengeng Liu,YueWei,JianminWang,Langan Pi,Jianjun Huang&Peichang Wang.(2012).Carbonic Anhydrases III and IV Autoantibodies in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Diabetes, Hypertensive Renal Disease, and Heart Failure.CLINICAL & DEVELOPMENTAL IMMUNOLOGY,2012,
MLA：
Chengeng Liu,et al."Carbonic Anhydrases III and IV Autoantibodies in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Diabetes, Hypertensive Renal Disease, and Heart Failure".CLINICAL & DEVELOPMENTAL IMMUNOLOGY 2012.(2012)
