机构：[1]Department of Physiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing 100069, China[2]Department of Neurology, Stanford University, Stanford, CA 94305, USA[3]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China神经外科首都医科大学宣武医院
Electroacupuncture (EA), especially high-frequency EA, has frequently been used as an alternative therapy for Parkinson disease (PD) and is reportedly effective for alleviating motor symptoms in patients and PD models. However, the molecular mechanism underlying its effectiveness is not completely understood. To implement a full-scale search for the targets of 100 Hz EA, we selected rat models treated with 6-hydroxydopamine into the unilateral MFB, which mimic end-stage PD. High-throughput microarray analysis was then used to uncover the regulated targets in the cortex and striatum after 4-week EA treatment. In the differentially regulated transcripts, the proportion of recovered expression profiles in the genes, the functional categories of targets in different profiles, and the affected pathways were analyzed. Our results suggested that the recovery of homeostasis in the transcript network and many regulated functional clusters in the cortex and striatum after EA treatment may contribute to the behavioral improvement of PD rats.
基金：
the National Basic Research Program of China (2011CB504100)
the National Natural Science Foundation of China (81072858)
the FP7 Good Practice in Traditional Chinese Medicine Research in the Postgenomic Era (223154)
第一作者机构：[1]Department of Physiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing 100069, China
通讯作者：
通讯机构：[1]Department of Physiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing 100069, China
推荐引用方式(GB/T 7714)：
Li-Rong Huo,Xi-Bin Liang,Bo Li,et al.The Cortical and Striatal Gene Expression Profile of 100 Hz Electroacupuncture Treatment in 6-Hydroxydopamine-Induced Parkinson's Disease Model[J].EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.2012,2012:doi:10.1155/2012/908439.
APA：
Li-Rong Huo,Xi-Bin Liang,Bo Li,Jian-Tao Liang,Yi He...&Xiao-MinWang.(2012).The Cortical and Striatal Gene Expression Profile of 100 Hz Electroacupuncture Treatment in 6-Hydroxydopamine-Induced Parkinson's Disease Model.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2012,
MLA：
Li-Rong Huo,et al."The Cortical and Striatal Gene Expression Profile of 100 Hz Electroacupuncture Treatment in 6-Hydroxydopamine-Induced Parkinson's Disease Model".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2012.(2012)
