机构：[a]Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, PR China神经内科首都医科大学宣武医院[b]Laboratory of Chronobiology and Chronomedicine, Beijing Geriatric Medical Research Center, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, PR China[c]UCLA-Kern Psychiatry Programs, Kern Medical Center and Kern County Mental Health, United States[d]Psychiatry and Human Behavior, UC Irvine School of Medicine, United States
Several studies have indicated that three PITX3 single nucleotide polymorphisms (SNPs), rs2281983, rs4919621 and rs3758549, are likely to be associated with Parkinson's disease (PD) in Caucasians. Some studies also suggested an age-of-onset effect. We recently reported that allele and genotype frequencies did not differ between late-onset PD (LOPD) patients and controls for all three SNPs. To extend the analysis to early-onset PD (EOPD) patients, and to test whether an age-of-onset effect exists in Chinese, we genotyped these SNPs in 290 Chinese EOPD patients using a ligase detection reaction (LDR). For all three SNPs, allele and genotype frequencies did not differ between total PD patients and controls, between LOPD patients and controls, between EOPD patients and controls, or between LOPD and EOPD patients. Our results suggest that these PITX3 SNPs do not contribute to the risk of developing PD in EOPD or LOPD in Chinese. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
基金：
the National Natural Science Foundation of China (81071011)
the National 973 Project Grant of China (2011CBA00408)
the Program for New Century Excellent Talents in University (NCET-10-0013)
the Scientific Project of Beijing Municipal Science & Technology Commission (D07050701350703,D07050701350706)
第一作者机构：[a]Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, PR China[b]Laboratory of Chronobiology and Chronomedicine, Beijing Geriatric Medical Research Center, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, PR China[*1]Department of Neurobiology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, PR China.
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Neurobiology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, PR China.[*2]Department of Neurology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, PR China.
推荐引用方式(GB/T 7714)：
Yanning Cai,Hui Ding,Zhuqin Gu,et al.PITX3 polymorphism is not associated with Parkinson's disease in a Chinese population[J].NEUROSCIENCE LETTERS.2011,505(3):260-262.doi:10.1016/j.neulet.2011.10.034.
APA：
Yanning Cai,Hui Ding,Zhuqin Gu,Andrius Baskys,Jinghong Ma&Piu Chan.(2011).PITX3 polymorphism is not associated with Parkinson's disease in a Chinese population.NEUROSCIENCE LETTERS,505,(3)
MLA：
Yanning Cai,et al."PITX3 polymorphism is not associated with Parkinson's disease in a Chinese population".NEUROSCIENCE LETTERS 505..3(2011):260-262
