机构：[a]Department of Radiology, the 4th Medical College of Peking University, Beijing Jishuitan Hospital, Beijing 100035, China[b]Beijing Normal University, State Key Laboratory of Cognitive Neuroscience and Learning, Beijing 100875, China[c]Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, China神经外科首都医科大学宣武医院[d]Department of Radiology, Xuanwu Hospital, Capital University of Medical Sciences, China放射科首都医科大学宣武医院[e]Department of Neurology, Xuanwu Hospital, Capital University of Medical Sciences, China神经内科首都医科大学宣武医院
Purpose: The purpose of this study was to investigate the abnormality of language networks in left medial temporal lobe epilepsy (MTLE) using fMRI. Materials and methods: Eight patients with left MTLE and 15 healthy subjects were evaluated. An auditory semantic judgment (AJ) paradigm was used. The fMRI data were collected on a 3T MR system and analyzed by AFNI (analysis of functional neuroimages) to generate the activation map. Results: Behavioral data showed that the reaction time of the left MTLE patients was significantly longer than that of controls on the AJ task (t = -3.396, P < 0.05). The left MTLE patients also exhibited diffusively decreased activation in the AJ task. Right hemisphere dominance of Broca's and Wernicke's areas was demonstrated in left MTLE patients. Conclusions: Long-term activation of spikes in left MTLE patients results in language impairment, which is associated with an abnormality of the brain neural network. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
基金：
the National Natural Science Foundation of China (General Program, Grant No. 30800265)
China Postdoctoral Science Foundation (Special Program, Grant No.200902121)
第一作者机构：[a]Department of Radiology, the 4th Medical College of Peking University, Beijing Jishuitan Hospital, Beijing 100035, China
通讯作者：
通讯机构：[a]Department of Radiology, the 4th Medical College of Peking University, Beijing Jishuitan Hospital, Beijing 100035, China
推荐引用方式(GB/T 7714)：
Aihong Yu,Xiaoyi Wang,Guoqing Xu,et al.A functional MRI study of language networks in left medial temporal lobe epilepsy[J].EUROPEAN JOURNAL OF RADIOLOGY.2011,80(2):441-444.doi:10.1016/j.ejrad.2010.06.017.
APA：
Aihong Yu,Xiaoyi Wang,Guoqing Xu,Yongjie Li,Wen Qin...&Yuping Wang.(2011).A functional MRI study of language networks in left medial temporal lobe epilepsy.EUROPEAN JOURNAL OF RADIOLOGY,80,(2)
MLA：
Aihong Yu,et al."A functional MRI study of language networks in left medial temporal lobe epilepsy".EUROPEAN JOURNAL OF RADIOLOGY 80..2(2011):441-444
