Amnestic Mild Cognitive Impairment: Functional MR Imaging Study of Response in Posterior Cingulate Cortex and Adjacent Precuneus during Problem-solving Tasks
机构：[1]Department of Radiology (MRI Room), Meitan General Hospital, Beijing, China[2]Department of Radiology, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xuanwu District, Beijing, China 100053放射科首都医科大学宣武医院[3]International WIC Institute, Beijing University of Technology, Beijing, China[4]Department of Neurology, PLA General Hospital, Beijing, China[5]Department of Life Science and Informatics, Maebashi Institute of Technology, Maebashi, Japan
Purpose: To compare the blood oxygen level-dependent (BOLD) response, measured with functional magnetic resonance (MR) imaging, in the posterior cingulate cortex (PCC) and adjacent precuneus regions between healthy control subjects and patients with amnestic mild cognitive impairment (MCI) during problem-solving tasks. Materials and Methods: This study was approved by the institutional review board. Each subject provided written informed consent. Thirteen patients with amnestic MCI and 13 age-and sex-matched healthy control subjects participated in the study. The functional magnetic resonance (MR) imaging tasks were simplified 4 x 4-grid number placement puzzles that were divided into a simple task (using the row rule or the column rule to solve the puzzle) and a complex task (using both the row and column rules to solve the puzzle). Behavioral results and functional imaging results between the healthy control group and the amnestic MCI group were analyzed. Results: The accuracy for the complex task in the healthy control group was significantly higher than that in the amnestic MCI group (P < .05). The healthy control group exhibited a deactivated BOLD signal intensity (SI) change in the bilateral PCC and adjacent precuneus regions during the complex task, whereas the amnestic MCI group showed activation. The positive linear correlations between the BOLD SI change in bilateral PCC and adjacent precuneus regions and in bilateral hippocampi in the amnestic MCI group were significant (P < .001), while in the healthy control group, they were not (P >= .23). Conclusion: These findings suggest that an altered BOLD response in amnestic MCI patients during complex tasks might be related to a decline in problem-solving ability and to memory impairment and, thus, may indicate a compensatory response to memory impairment. (C) RSNA, 2011
基金：
National Natural Science Foundation of China (grants 60875075 and 81000606)
第一作者机构：[1]Department of Radiology (MRI Room), Meitan General Hospital, Beijing, China[2]Department of Radiology, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xuanwu District, Beijing, China 100053
通讯作者：
通讯机构：[2]Department of Radiology, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xuanwu District, Beijing, China 100053
推荐引用方式(GB/T 7714)：
Guangwei Jin,Kuncheng Li,Yingying Hu,et al.Amnestic Mild Cognitive Impairment: Functional MR Imaging Study of Response in Posterior Cingulate Cortex and Adjacent Precuneus during Problem-solving Tasks[J].RADIOLOGY.2011,261(2):525-533.doi:10.1148/radiol.11102186.
APA：
Guangwei Jin,Kuncheng Li,Yingying Hu,Yulin Qin,Xiangqing Wang...&Ning Zhong.(2011).Amnestic Mild Cognitive Impairment: Functional MR Imaging Study of Response in Posterior Cingulate Cortex and Adjacent Precuneus during Problem-solving Tasks.RADIOLOGY,261,(2)
MLA：
Guangwei Jin,et al."Amnestic Mild Cognitive Impairment: Functional MR Imaging Study of Response in Posterior Cingulate Cortex and Adjacent Precuneus during Problem-solving Tasks".RADIOLOGY 261..2(2011):525-533
医学