机构：[1]Departments of Radiology,Xuanwu Hospital of Capital Medical University, Beijing 100053, China放射科首都医科大学宣武医院[2]Departments of Neurology,Xuanwu Hospital of Capital Medical University, Beijing 100053, China神经内科首都医科大学宣武医院[3]Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology[4]Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts 02129,[5]Psychology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138[6]Howard Hughes Medical Institute, Cambridge,Massachusetts 02138
Intrinsic functional connectivity detected by functional MRI (fMRI) provides a useful but indirect approach to study the organization of human brain systems. An unresolved question is whether functional connectivity measured by resting-state fMRI reflects anatomical connections. In this study, we used the well-characterized anatomy of cerebrocerebellar circuits to directly test whether intrinsic functional connectivity is associated with an anatomic pathway. Eleven first-episode stroke patients were scanned five times during a period of 6 months, and 11 healthy control subjects were scanned three times within 1 month. In patients with right pontine strokes, the functional connectivity between the right motor cortex and the left cerebellum was selectively reduced. This connectivity pattern was reversed in patients with left pontine strokes. Although factors beyond anatomical connectivity contribute to fMRI measures of functional correlation, these results provide direct evidence that functional connectivity depends on intact connections within a specific polysynaptic pathway.
基金：
NINDS (Grant K25NS069805）
NIA (Grant AG021910）
NCRR (Grant P41RR14074）
Howard Hughes Medical Institute
第一作者机构：[1]Departments of Radiology,Xuanwu Hospital of Capital Medical University, Beijing 100053, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China,[*2]Psychology and Center for Brain Science, Harvard University, Cambridge, MA 02138,
推荐引用方式(GB/T 7714)：
Jie Lu,Hesheng Liu,Miao Zhang,et al.Focal Pontine Lesions Provide Evidence That Intrinsic Functional Connectivity Reflects Polysynaptic Anatomical Pathways[J].JOURNAL OF NEUROSCIENCE.2011,31(42):15065-15071.doi:10.1523/JNEUROSCI.2364-11.2011.
APA：
Jie Lu,Hesheng Liu,Miao Zhang,Danhong Wang,Yanxiang Cao...&Kuncheng Li.(2011).Focal Pontine Lesions Provide Evidence That Intrinsic Functional Connectivity Reflects Polysynaptic Anatomical Pathways.JOURNAL OF NEUROSCIENCE,31,(42)
MLA：
Jie Lu,et al."Focal Pontine Lesions Provide Evidence That Intrinsic Functional Connectivity Reflects Polysynaptic Anatomical Pathways".JOURNAL OF NEUROSCIENCE 31..42(2011):15065-15071
医学