机构：[a]Department of Neurology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, PR China神经内科神经变性病教育部重点实验室首都医科大学宣武医院[b]Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, PR China神经变性病教育部重点实验室首都医科大学宣武医院
PITX3 is a transcription factor which determines the survival of dopaminergic neurons in the substantia nigra, and is considered a candidate gene for Parkinson's disease (PD). Recent association studies indicated that three PITX3 single nucleotide polymorphisms (SNPs), including rs2281983, rs4919621, and rs3758549 are likely to be associated with PD. However, no similar associations in Chinese populations have been reported. To examine the nature of the association in Chinese individuals we analyzed DNA samples for these three PTIX3 SNPs from 509 late-onset sporadic PD patients, and 494 healthy controls, using a ligase detection reaction (LDR). Results indicated that allele and genotype frequencies did not differ between patients and controls for all three SNPs, suggesting that these SNP sites do not contribute to the risk of developing PD in late-onset sporadic PD in this Chinese population. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
基金：
National Natural Science Foundation of China (81071011 and 30400148),
the National 973 Project Grant of China (2006CB943703, 2007CB947704, and 2011CBA00408),
the National 863 Project Grant of China (2006AA02A408, 2006AA02A112, and 2006AA02A114), and the
Scientific Project of Beijing Municipal Science & Technology Commission (D07050701350703 and D07050701350706).
第一作者机构：[a]Department of Neurology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, PR China[b]Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, PR China[*1]Department of Neurobiology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, PR China.
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Neurobiology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, PR China.[*2]Department of Neurology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, PR China.
推荐引用方式(GB/T 7714)：
Yanning Cai,Hui Ding,huqin Gu,et al.Genetic variants of the PITX3 gene are not associated with late-onset sporadic Parkinson's disease in a Chinese population[J].NEUROSCIENCE LETTERS.2011,498(2):124-126.doi:10.1016/j.neulet.2011.04.073.
APA：
Yanning Cai,Hui Ding,huqin Gu,Jinghong Ma&Piu Chan.(2011).Genetic variants of the PITX3 gene are not associated with late-onset sporadic Parkinson's disease in a Chinese population.NEUROSCIENCE LETTERS,498,(2)
MLA：
Yanning Cai,et al."Genetic variants of the PITX3 gene are not associated with late-onset sporadic Parkinson's disease in a Chinese population".NEUROSCIENCE LETTERS 498..2(2011):124-126
