机构：[a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China神经内科首都医科大学宣武医院[b]State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, 100875, China[c]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China放射科首都医科大学宣武医院
Here we utilized resting-state functional magnetic resonance imaging (R-fMRI) to measure the amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF) in 24 patients with amnestic mild cognitive impairment (aMCI) and 24 age- and sex-matched healthy controls. Two different frequency bands (slow-5: 0.01-0.027 Hz; slow-4: 0.027-0.073 Hz) were analyzed. We showed that there were widespread differences in ALFF/fALFF between the two bands in many brain regions, predominantly including the medial prefrontal cortex (MPFC), posterior cingulate cortex/precuneus (PCC/PCu), basal ganglia, and hippocampus/parahippocampal gyrus (PHG). Compared to controls, the aMCI patients had decreased ALFF/fALFF values in the PCC/PCu, MPFC, hippocampus/PHG, basal ganglia, and prefrontal regions, and increased ALFF/fALFF values mainly in several occipital and temporal regions. Specifically, we observed that the ALFF/fALFF abnormalities in the PCC/PCu, PHG, and several occipital regions were greater in the slow-5 band than in the slow-4 band. Finally, our results of functional analysis were not significantly influenced by the gray matter loss in the MCI patients, suggesting that the results reflect functional differences between groups. Together, our data suggest that aMCI patients have widespread abnormalities in intrinsic brain activity, and the abnormalities depend on the studied frequency bands of R-fMRI data. (C) 2010 Elsevier Inc. All rights reserved.
基金：
National Natural Science Foundation of China (grants 30970823, 81030028, 30870667 and 30830045).
语种：
外文
高被引：
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2010]版：
大类|2 区医学
小类|1 区核医学2 区神经成像2 区神经科学
最新[2023]版：
大类|2 区医学
小类|1 区神经成像2 区神经科学2 区核医学
JCR分区：
出版当年[2009]版：
Q1NEUROSCIENCESQ1NEUROIMAGINGQ1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q1NEUROIMAGINGQ1NEUROSCIENCESQ1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者机构：[a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China
通讯作者：
通讯机构：[a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China
推荐引用方式(GB/T 7714)：
Ying Han,Jinhui Wang,Zhilian Zhao,et al.Frequency-dependent changes in the amplitude of low-frequency fluctuations in amnestic mild cognitive impairment: A resting-state fMRI study[J].NEUROIMAGE.2011,55(1):287-295.doi:10.1016/j.neuroimage.2010.11.059.
APA：
Ying Han,Jinhui Wang,Zhilian Zhao,Baoquan Min,Jie Lu...&Jianping Jia.(2011).Frequency-dependent changes in the amplitude of low-frequency fluctuations in amnestic mild cognitive impairment: A resting-state fMRI study.NEUROIMAGE,55,(1)
MLA：
Ying Han,et al."Frequency-dependent changes in the amplitude of low-frequency fluctuations in amnestic mild cognitive impairment: A resting-state fMRI study".NEUROIMAGE 55..1(2011):287-295
医学