机构：[1]Beijing Institute of Geriatrics and Department of Neurobiology and Neurology, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Xuanwu Hospital of Capital Medical University, #45 Changchun Street, Beijing 100053, China神经内科老年医学科神经变性病教育部重点实验室首都医科大学宣武医院
Abundant evidence has suggested that neuroinflammation participates in the pathogenesis of Parkinson's disease (PD). The emerging evidence has supported that microglia may play key roles in the progressive neurodegeneration in PD and might be a promising therapeutic target. Ganoderma lucidum (GL), a traditional Chinese medicinal herb, has been shown potential neuroprotective effects in our clinical trials that make us to speculate that it might possess potent anti-inflammatory and immunomodulating properties. To test this hypothesis, we investigated the potential neuroprotective effect of GL and possible underlying mechanism of action through protecting microglial activation using co-cultures of dopaminergic neurons and microglia. The microglia is activated by LPS and MPP+-treated MES 23.5 cell membranes. Meanwhile, GL extracts significantly prevent the production of microglia-derived proinflammatory and cytotoxic factors [nitric oxide, tumor necrosis factor-alpha (TNF-alpha), interlukin 1 beta (IL-1 beta)] in a dose-dependent manner and down-regulate the TNF-alpha and IL-1 beta expressions on mRNA level as well. In conclusion, our results support that GL may be a promising agent for the treatment of PD through anti-inflammation.
基金：
Ministry of Sciences and Technology of China grants (2004BA702B02, 2006CB500701, 2006AA02A408).
第一作者机构：[1]Beijing Institute of Geriatrics and Department of Neurobiology and Neurology, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Xuanwu Hospital of Capital Medical University, #45 Changchun Street, Beijing 100053, China
通讯作者：
通讯机构：[1]Beijing Institute of Geriatrics and Department of Neurobiology and Neurology, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Xuanwu Hospital of Capital Medical University, #45 Changchun Street, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Ruiping Zhang,Shengli Xu,Yanning Cai,et al.Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation[J].EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.2011,2011:doi:10.1093/ecam/nep075.
APA：
Ruiping Zhang,Shengli Xu,Yanning Cai,Ming Zhou,Xiaohong Zuo&Piu Chan.(2011).Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2011,
MLA：
Ruiping Zhang,et al."Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2011.(2011)
