机构：[1]Department of Dermatology and Venerology, The Affiliated Hospital of Inner Mongolia Medical College, Hohhot, China[2]Department of Dermatology and Venerology, Xuan Wu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院
P>Background. Fas and FasL are cell-surface receptors involved in apoptosis. Aim. To investigate Fas and FasL expression levels in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) to gain an insight into the mechanisms of Fas/FasL apoptosis and immune evasion in epidermal tumours. Methods. Real-time PCR and streptavidin-biotin immunohistochemistry techniques were used to detect Fas and FasL expression in BCC, SCC and normal skin specimens. Results. Fas and FasL mRNA expression and immunostaining levels were lower in the 21 BCC specimens than in normal skin, whereas they were higher in the 15 SCC specimens than in normal skin. Conclusion. FasL immunostaining correlated with the capability of the tumour to invade and metastasize; the absent or weak immunostaining in the BCC specimens correlated with low capability, and the strong staining in the SCC specimens correlated with high capability.
基金：
the Inner Mongolia Natural Science Fund (No 200711020924)
第一作者机构：[1]Department of Dermatology and Venerology, The Affiliated Hospital of Inner Mongolia Medical College, Hohhot, China[*1]Department of Dermatology and Venerology, The Affiliated Hospital of Inner Mongolia Medical College, 1 Tongdao North Street, Hohhot 010050, China
通讯作者：
通讯机构：[*1]Department of Dermatology and Venerology, The Affiliated Hospital of Inner Mongolia Medical College, 1 Tongdao North Street, Hohhot 010050, China
推荐引用方式(GB/T 7714)：
X.-Y. Wang,R. Zhang,S. Lian.Aberrant expression of Fas and FasL pro-apoptotic proteins in basal cell and squamous cell carcinomas[J].CLINICAL AND EXPERIMENTAL DERMATOLOGY.2011,36(1):69-76.doi:10.1111/j.1365-2230.2010.03860.x.
APA：
X.-Y. Wang,R. Zhang&S. Lian.(2011).Aberrant expression of Fas and FasL pro-apoptotic proteins in basal cell and squamous cell carcinomas.CLINICAL AND EXPERIMENTAL DERMATOLOGY,36,(1)
MLA：
X.-Y. Wang,et al."Aberrant expression of Fas and FasL pro-apoptotic proteins in basal cell and squamous cell carcinomas".CLINICAL AND EXPERIMENTAL DERMATOLOGY 36..1(2011):69-76
