机构：[1]Institute of Automation, Chinese Academy of Sciences, Beijing, China[2]Department of Radiology and National Key Lab of Neurodegenerative Disease, Xuanwu Hospital, Capital Medical University, Beijing, China放射科首都医科大学宣武医院[3]Departments of Psychiatry and Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida.
BACKGROUND AND PURPOSE: Depression occurs frequently in PD; however the neural basis of depression in PD remains unclear. The aim of this study was to characterize possible depression-related white matter microstructural changes in the thalamus of patients with DPD compared with those with NDPD. MATERIALS AND METHODS: FA and MD maps from DTI were obtained in 14 patients with DPD and 18 patients with NDPD. Region-of-interest-guided VBA was conducted on the FA maps to detect possible microstructural differences in the thalamus between these 2 patient groups. Moreover, mean FA and MD in regions with a detected difference were compared between DPD and NDPD groups, and correlations between diffusion quantities and the severity of depression were analyzed. RESULTS: White matter microstructure differences were found between the patients with DPD and NDPD in the bilateral mediodorsal thalamic regions. In these regions, patients with DPD showed significantly decreased FA values (P < .005) compared with patients with NDPD, and the mean values of FA were negatively correlated with the scores of depression severity (P < .05) for patients with PD. No significant differences of MD were found in the mediodorsal thalamus between these 2 groups. CONCLUSIONS: Our results provide preliminary evidence that the mediodorsal thalamus may play an important role in depression in PD and suggest a relationship between FA in the mediodorsal thalamus and the presence of depressive symptoms in patients with DPD. These findings may be helpful for further understanding the potential mechanisms of depression in PD.
基金：
the National Natural Science Foundation of China grants 30970769, 60532050, 60910006, 30770620, 30970771; and CAS Hundred Talents Program grant YZ200766.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2009]版：
大类|3 区医学
小类|3 区临床神经病学3 区神经成像3 区核医学
最新[2023]版：
大类|3 区医学
小类|3 区临床神经病学3 区神经成像3 区核医学
JCR分区：
出版当年[2008]版：
Q1NEUROIMAGINGQ2CLINICAL NEUROLOGYQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ2CLINICAL NEUROLOGYQ2NEUROIMAGING
第一作者机构：[1]Institute of Automation, Chinese Academy of Sciences, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[*1]Institute of Automation, Chinese Academy of Sciences, No. 95 Zhongguancun East Rd, Haidian District, Beijing, 100190, China[*2]Department of Radiology, Xuanwu Hospital, Capital Medical University, No. 45 Changchun St, Beijing 100053, China
推荐引用方式(GB/T 7714)：
W. Li,J. Liu,F. Skidmore,et al.White Matter Microstructure Changes in the Thalamus in Parkinson Disease with Depression: A Diffusion Tensor MR Imaging Study[J].AMERICAN JOURNAL OF NEURORADIOLOGY.2010,31(10):1861-1866.doi:10.3174/ajnr.A2195.
APA：
W. Li,J. Liu,F. Skidmore,Y. Liu,J. Tian&K. Li.(2010).White Matter Microstructure Changes in the Thalamus in Parkinson Disease with Depression: A Diffusion Tensor MR Imaging Study.AMERICAN JOURNAL OF NEURORADIOLOGY,31,(10)
MLA：
W. Li,et al."White Matter Microstructure Changes in the Thalamus in Parkinson Disease with Depression: A Diffusion Tensor MR Imaging Study".AMERICAN JOURNAL OF NEURORADIOLOGY 31..10(2010):1861-1866
