A significant percentage of patients with gastroesophageal reflux disease may experience extraesophageal manifestations, such as chest pain or asthma. These symptoms are more difficult to diagnose than the usual esophageal symptoms. The aim of this article is to characterize the extraesophageal manifestations in patients with gastroesophageal reflux disease and report the effects of the Stretta procedure. We report a case of a 59-year-old female patient with a history of arrhythmia. She was referred for the Stretta procedure in the gastroesophageal junction after her symptoms were documented by pH monitoring and proton-pump inhibitors treatment to be associated with acid reflux. The long-standing arrhythmia improved after the Stretta procedure. To our knowledge, this is a rare case of successful Stretta procedure treatment of a patient with cardiovascular manifestations induced by gastroesophageal reflux disease. The results indicate an underlying mechanism for extraesophageal manifestations and the success of the Stretta procedure.