机构：[1]Institute of Basic Medical Sciences, Department of Biostatistics, University of Oslo, Oslo, Norway[2]MRC Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK[3]Department of Community Medicine, University of Hong Kong, Hong Kong, China[4]The George Institute for International Health, University of Sydney, Sydney, Australia[5]Department of and Social Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院[6]Centre of Research and Promotion of Women’s Health, School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong, China[7]Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea[8]Health Promotion Research Centre, Zahedan University of Medical Sciences, Zahedan, Iran[9]School of Public Health and Clinical Practice, University of Adelaide, Adelaide, Australia[10]Department of Health Science, Shiga University of Medical Science, Shiga, Japan[11]Department of Epidemiology,Johns Hopkins University, Baltimore, MD, USA[12]Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
Background Excess bodyweight is an established risk factor for several types of cancer, but there are sparse data from Asian populations, where the proportion of overweight and obese individuals is increasing rapidly and adiposity can be substantially greater for the same body-mass index (BMI) compared with people from Western populations. Methods We examined associations of adult BMI with cancer mortality (overall and for 20 cancer sites) in geographic populations from Asia and from Australia and New Zealand (ANZ), within the Asia-Pacific Cohort Studies Collaboration, by use of Cox regression analysis. Pooled data from 39 cohorts (recruitment 1961-99, median follow-up 4 years) were analysed for 424519 participants (77% Asian; 41% female; mean recruitment age 48 years) with individual data on BMI. Findings After excluding those with follow-up of less than 3 years, 4872 cancer deaths occurred in 401 215 participants. Hazard ratios for cancer sites with increased mortality risk in obese (BMI >= 30 kg/m(2)) compared with normal weight participants (BMI 18.5-24.9 kg/m(2)) were: 1.21 (95% CI 1.09-1.36) for all-cause cancer (excluding lung and upper aerodigestive tract), 1.50 (1.13-1.99) for colon, 1.68 (1.06-2.67) for rectum, 1.63 (1.13-2.35) for breast in women 60 years or older, 2.62 (1.57-4.37) for ovary, 4.21 (1.89-9.39) for cervix, 1.45 (0.97-2.19) for prostate, and 1.66 (1.03-2.68) for leukaemia (all after left censoring at 3 years). The increased risk associated with a 5-unit increase in BMI for those with BMI of 18.5 kg/m(2) or higher was 1.09 (95% CI 1.04-1.14) for all cancers (excluding lung and upper aerodigestive tract). There was little evidence of regional differences in relative risk of cancer with higher BMI, apart from cancers of the oropharynx and larynx, where the association was inverse in ANZ and absent in Asia. Interpretation Overweight and obese individuals in populations across the Asia-Pacific region have a significantly increased risk of mortality from cancer. Strategies to prevent individuals from becoming overweight and obese in Asia are needed to reduce the burden of cancer that is expected if the obesity epidemic continues
基金：
Norwegian Foundation for Health and Rehabilitation via the Norwegian Cancer Society; the UK Wellcome Trust; Seoul City Research and Business Development Program (10526);
New South Wales and Heart Foundation Career Development Award
第一作者机构：[1]Institute of Basic Medical Sciences, Department of Biostatistics, University of Oslo, Oslo, Norway[4]The George Institute for International Health, University of Sydney, Sydney, Australia[*]Department of Biostatistics, University of Oslo, PO Box 1122 Blindern, N-0317 Oslo, Norway
通讯作者：
通讯机构：[*]Department of Biostatistics, University of Oslo, PO Box 1122 Blindern, N-0317 Oslo, Norway
推荐引用方式(GB/T 7714)：
Christine L Parr,G David Batty,Tai Hing Lam,et al.Body-mass index and cancer mortality in the Asia-Pacific Cohort Studies Collaboration: pooled analyses of 424 519 participants[J].LANCET ONCOLOGY.2010,11(8):741-752.doi:10.1016/S1470-2045(10)70141-8.
APA：
Christine L Parr,G David Batty,Tai Hing Lam,Federica Barzi,Xianghua Fang...&Rachel R Huxley.(2010).Body-mass index and cancer mortality in the Asia-Pacific Cohort Studies Collaboration: pooled analyses of 424 519 participants.LANCET ONCOLOGY,11,(8)
MLA：
Christine L Parr,et al."Body-mass index and cancer mortality in the Asia-Pacific Cohort Studies Collaboration: pooled analyses of 424 519 participants".LANCET ONCOLOGY 11..8(2010):741-752
医学