机构:[1]Department of Pharmacology, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Xuanwu Hospital of Capital Medical University, 45 Chang-chun Street, 100053 Beijing, People’s Republic of China神经变性病教育部重点实验室首都医科大学宣武医院药物学研究室实验动物室[2]Department of Neurology, Affiliated Hospital of Inner Mongolia Medical College, 010059 Hohhot, Inner Mongolia, People’s Republic of China
The capacity of cornel iridoid glycoside (CIG) to suppress the manifestations of ischemic stroke was investigated. CIG was administered to rats by the intragastric route once daily for 7 days. Focal cerebral ischemia was induced by 2 h of middle cerebral artery occlusion followed by 24 h of reperfusion. In non-treated rats large infarct areas were observed within 24 h of reperfusion. Examination of the ischemic cerebral cortex revealed microglia and astrocyte activation, increased interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) concentrations, increased DNA fragmentation in the ischemia penumbra, elevated Bax expression, increased caspase-3 cleavage, and decreased Bcl-2 expression. Pretreatment with CIG decreased the infarct area, DNA fragmentation, IL-1 beta and TNF-alpha concentrations, microglia and astrocyte activation, Bax expression, and caspase-3 cleavage while increasing Bcl-2 expression. CIG exerts anti-neuroinflammatory and anti-apoptotic effects which should prove beneficial for prevention or treatment of stroke.
基金:
the National Key Basic Research 973 Program of China (Grant No. 2003CB517104), the National Natural Science Foundation of China (Grant No. 90709011, 30973513),
and the Beijing Municipal Science and Technology Program of China (Grant No. D0206001043191).
第一作者机构:[1]Department of Pharmacology, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Xuanwu Hospital of Capital Medical University, 45 Chang-chun Street, 100053 Beijing, People’s Republic of China
通讯作者:
通讯机构:[1]Department of Pharmacology, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Xuanwu Hospital of Capital Medical University, 45 Chang-chun Street, 100053 Beijing, People’s Republic of China
推荐引用方式(GB/T 7714):
Bai-liu Ya,Chun-yang Li,Lan Zhang,et al.Cornel Iridoid Glycoside Inhibits Inflammation and Apoptosis in Brains of Rats with Focal Cerebral Ischemia[J].NEUROCHEMICAL RESEARCH.2010,35(5):773-781.doi:10.1007/s11064-010-0134-2.
APA:
Bai-liu Ya,Chun-yang Li,Lan Zhang,Wen Wang&Lin Li.(2010).Cornel Iridoid Glycoside Inhibits Inflammation and Apoptosis in Brains of Rats with Focal Cerebral Ischemia.NEUROCHEMICAL RESEARCH,35,(5)
MLA:
Bai-liu Ya,et al."Cornel Iridoid Glycoside Inhibits Inflammation and Apoptosis in Brains of Rats with Focal Cerebral Ischemia".NEUROCHEMICAL RESEARCH 35..5(2010):773-781