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Cornel Iridoid Glycoside Inhibits Inflammation and Apoptosis in Brains of Rats with Focal Cerebral Ischemia

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机构: [1]Department of Pharmacology, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Xuanwu Hospital of Capital Medical University, 45 Chang-chun Street, 100053 Beijing, People’s Republic of China [2]Department of Neurology, Affiliated Hospital of Inner Mongolia Medical College, 010059 Hohhot, Inner Mongolia, People’s Republic of China
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关键词: Cornus Iridoid glycosides Focal cerebral ischemia Cerebral infarction Neuroinflammation Apoptosis

摘要:
The capacity of cornel iridoid glycoside (CIG) to suppress the manifestations of ischemic stroke was investigated. CIG was administered to rats by the intragastric route once daily for 7 days. Focal cerebral ischemia was induced by 2 h of middle cerebral artery occlusion followed by 24 h of reperfusion. In non-treated rats large infarct areas were observed within 24 h of reperfusion. Examination of the ischemic cerebral cortex revealed microglia and astrocyte activation, increased interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) concentrations, increased DNA fragmentation in the ischemia penumbra, elevated Bax expression, increased caspase-3 cleavage, and decreased Bcl-2 expression. Pretreatment with CIG decreased the infarct area, DNA fragmentation, IL-1 beta and TNF-alpha concentrations, microglia and astrocyte activation, Bax expression, and caspase-3 cleavage while increasing Bcl-2 expression. CIG exerts anti-neuroinflammatory and anti-apoptotic effects which should prove beneficial for prevention or treatment of stroke.

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出版当年[2009]版:
大类 | 4 区 医学
小类 | 4 区 生化与分子生物学 4 区 神经科学
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 生化与分子生物学 3 区 神经科学
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出版当年[2008]版:
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 NEUROSCIENCES
最新[2023]版:
Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 NEUROSCIENCES

影响因子: 最新[2023版] 最新五年平均 出版当年[2008版] 出版当年五年平均 出版前一年[2007版] 出版后一年[2009版]

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第一作者机构: [1]Department of Pharmacology, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Xuanwu Hospital of Capital Medical University, 45 Chang-chun Street, 100053 Beijing, People’s Republic of China
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通讯机构: [1]Department of Pharmacology, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Xuanwu Hospital of Capital Medical University, 45 Chang-chun Street, 100053 Beijing, People’s Republic of China
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