机构：[a]Department of Radiology, Xuanwu Hospital of Capital University of Medical Sciences, Beijing 100053, PR China放射科首都医科大学宣武医院[b]Department of Neurology, Xuanwu Hospital of Capital University of Medical Sciences, Beijing 100053, PR China神经内科首都医科大学宣武医院[c]School of Information Science and Technology, Beijing Normal University, Beijing 100875, PR China[d]Key Laboratory of Neurodegenerative Diseases (Capital University of Medical Sciences), Ministry of Education, Beijing 100053, PR China
Mild cognitive impairment (MCI) is the transitional, heterogeneous continuum from healthy elderly to Alzheimer's disease (AD). Previous studies have shown that brain functional activity in the default mode network (DMN) is impaired in AD patients. However, altering DMN activity patterns in MCI patients remains largely unclear. The present study utilized resting-state functional magnetic resonance imaging (fMRI) and an independent component analysis (ICA) approach to investigate DMN activity in 14 amnestic MCI (aMCI) patients and 14 healthy elderly. Compared to the aMCI patients, the healthy elderly exhibited increased functional activity in the DMN regions, including the bilateral precuneus/posterior cingulate cortex, right inferior parietal lobule, and left fusiform gyrus, as well as a trend towards increased right medial temporal lobe activity. The aMCI patients exhibited increased activity in the left prefrontal cortex, inferior parietal lobule, and middle temporal gyrus compared to the healthy elderly. Increased frontal-parietal activity may indicate compensatory processes in the aMCI patients. These findings suggest that abnormal DMN activity could be useful as an imaging-based biomarker for the diagnosis and monitoring of aMCI patients. (C) 2009 Elsevier Inc. All rights reserved.
基金：
Natural Science Foundation of China, Grant 30770620.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2009]版：
大类|2 区医学
小类|1 区神经成像1 区核医学2 区神经科学
最新[2023]版：
大类|2 区医学
小类|1 区神经成像2 区神经科学2 区核医学
JCR分区：
出版当年[2008]版：
Q1NEUROSCIENCESQ1NEUROIMAGINGQ1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q1NEUROIMAGINGQ1NEUROSCIENCESQ1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者机构：[a]Department of Radiology, Xuanwu Hospital of Capital University of Medical Sciences, Beijing 100053, PR China[d]Key Laboratory of Neurodegenerative Diseases (Capital University of Medical Sciences), Ministry of Education, Beijing 100053, PR China
通讯作者：
通讯机构：[a]Department of Radiology, Xuanwu Hospital of Capital University of Medical Sciences, Beijing 100053, PR China
推荐引用方式(GB/T 7714)：
Zhigang Qi,Xia Wu,Zhiqun Wang,et al.Impairment and compensation coexist in amnestic MCI default mode network[J].NEUROIMAGE.2010,50(1):48-55.doi:10.1016/j.neuroimage.2009.12.025.
APA：
Zhigang Qi,Xia Wu,Zhiqun Wang,Nang Zhang,Huiqing Dong...&Kuncheng Li.(2010).Impairment and compensation coexist in amnestic MCI default mode network.NEUROIMAGE,50,(1)
MLA：
Zhigang Qi,et al."Impairment and compensation coexist in amnestic MCI default mode network".NEUROIMAGE 50..1(2010):48-55
医学