机构：[a]State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing 100875, P.R. China[b]Department of Psychology and Social Behavior, University of California, Irvine, CA 92697, USA[c]Department of Psychology, School of Education, Suzhou University, Suzhou 215021, P.R. China[d]Department of Radiology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, P.R. China放射科首都医科大学宣武医院[e]Stuttering Therapy Center, Beijing 100055, P.R. China
Using an fMRI-based classification approach and the structural equation modeling (SEM) method, this study examined the neural bases of atypical planning and execution processes involved in stuttering. Twelve stuttering speakers and 12 controls were asked to name pictures under different conditions (single-syllable. multi-syllable, or repeated-syllable) in the scanner. The contrasts between conditions provided information about planning and execution processes. The classification analysis showed that, as compared to non-stuttering controls, stuttering speakers' atypical planning of speech was evident in their neural activities in the bilateral inferior frontal gyrus (IFG) and right putamen and their atypical execution of speech was evident in their activations in the right cerebellum and insula, left premotor area (PMA), and angular gyrus (AG). SEM results further revealed two parallel neural circuits-the basal ganglia-IFG/PMA circuit and the cerebellum-PMA circuit-that were involved in atypical planning and execution processes of stuttering, respectively. The AG appeared to be involved in the interface of atypical planning and execution in stuttering. These results are discussed in terms of their implications to the theories about Stuttering and to clinical applications. (C) 2009 Elsevier Inc. All rights reserved.
基金：
Beijing Natural Science Foundation (7062037), National Natural Science Foundation of China (NSFC) (30900393), and Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT).
第一作者机构：[a]State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing 100875, P.R. China
通讯作者：
通讯机构：[a]State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing 100875, P.R. China
推荐引用方式(GB/T 7714)：
Chunming Lu,Chuansheng Chen,Ning Ning,et al.The neural substrates for atypical planning and execution of word production in stuttering[J].EXPERIMENTAL NEUROLOGY.2010,221(1):146-156.doi:10.1016/j.expneurol.2009.10.016.
APA：
Chunming Lu,Chuansheng Chen,Ning Ning,Guosheng Ding,Taomei Guo...&Chunlan Lin.(2010).The neural substrates for atypical planning and execution of word production in stuttering.EXPERIMENTAL NEUROLOGY,221,(1)
MLA：
Chunming Lu,et al."The neural substrates for atypical planning and execution of word production in stuttering".EXPERIMENTAL NEUROLOGY 221..1(2010):146-156
