机构：[1]School of Clinical Medicine, Southeast University, Nanjing, China[2]Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, China[3]Department of Psychiatry, Nanjing Brain Hospital, Nanjing, China[4]Department of Neurology, XuanWu Hospital, Capital Medical University, Beijing, China神经内科首都医科大学宣武医院
Background: The genetic region coding for low-density lipoprotein receptor-related protein1 (LRP1) is considered an intriguing susceptibility locus for Alzheimer's disease (AD). Amnestic mild cognitive impairment (aMCI) is characterized by episodic memory impairment and represents the prodromal stage of AD. Our aim in this study is to investigate the relationship between LRP1 genetic variation and aMCI, and the influence of LRP1 on cognitive performance. Methods: We performed a case-control association study analyzing five polymorphisms in LRP1 gene by TaqMan Assays-on-Demand SNP Genotyping. All samples were derived from Chinese subjects (109 cases, 104 healthy controls) and assessed using multi-dimension neuropsychological instruments. Results: We identified haplotypes within the region containing the LRP1 gene. Of these, haplotype TAA (T: rs1800194; A: rs11837145.- A: rs10876967) was significantly associated with aMCI, being over-represented in aMCI versus healthy controls. Haplotype TAA was associated with poor performance on episodic memory in all subjects. Conclusions: This study confirms the association between genetic variants in LRP1 and aMCI. Moreover, we have identified a relationship between LRP1 genetic variation and specific aspects of neurocognitive function. Our convergent results suggest that LRP1 plays an important role in cognitive function and possibly in the pathogenesis of aMCI.
基金：
National Basic Research Program of China (973 Program) (No. 2007CB512308 ), National Hi-Tech Research and Development Program of China (863 Program) (No. 2007AA0200Z435),
National Natural Science Foundation of China (No. 30825014), and National Key Technologies R&D Program during the 11th Fiveyear Plan Period (No. 2006BAI02B01 ).
第一作者机构：[1]School of Clinical Medicine, Southeast University, Nanjing, China[2]Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, China
通讯作者：
通讯机构：[*]Department of Neurology, affiliated ZhongDa Hospital of Southeast University, No. 87 DingJiaQiao Road, Nanjing, PR China, 210009
推荐引用方式(GB/T 7714)：
Yong M. Shi ,Hong Zhou ,Zhi J. Zhang ,et al.Association of the LRP1 gene and cognitive performance with amnestic mild cognitive impairment in elderly Chinese[J].INTERNATIONAL PSYCHOGERIATRICS.2009,21(6):1072-1080.doi:10.1017/S104161020999072X.
APA：
Yong M. Shi,,Hong Zhou,,Zhi J. Zhang,,Hui Yu,,Feng Bai,...&Jian P. Jia.(2009).Association of the LRP1 gene and cognitive performance with amnestic mild cognitive impairment in elderly Chinese.INTERNATIONAL PSYCHOGERIATRICS,21,(6)
MLA：
Yong M. Shi,,et al."Association of the LRP1 gene and cognitive performance with amnestic mild cognitive impairment in elderly Chinese".INTERNATIONAL PSYCHOGERIATRICS 21..6(2009):1072-1080
