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Preliminary Investigation of Seeding Mesenchymal Stem Cells on Biodegradable Scaffolds for Vascular Tissue Engineering In Vitro

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收录情况： ◇ SCIE

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机构： [1]Department of Thoracic Cardiovascular Surgery, FuXing Hospital, Capital Medical University [2]Department of Vascular Surgery, XuanWu Hospital, Capital Medical University [3]Beijing Institute of Technology, School of Materials Science and Engineering, Beijing, People’s Republic of China

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We used epsilon-caprolactone/L-lactide (PCLA) as a biodegradable scaffold and bone marrow (BM) mesenchymal stem cells (MSCs) as seeding cells for vascular tissue engineering: we expected MSCs to grow in the scaffolds in a bioreactor. The MSCs we used were from the BM of dogs, and vascular scaffolds were carried out on the electrospinning process of PCLA copolymers. MSCs expressed CD44 and CD105 but did not express CD34 or CD14 at an identical time point. Scaffolds were nontoxic to cells and were favorable for the growth and migration of MSCs. After culture in a bioreactor with mechanical stimulation, cells completely covered the surfaces of PCLA scaffolds and penetrated or infiltrated into the inside of the scaffold structure. ASAIO Journal 2009; 55:614-619.

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出版当年[2008]版：

大类 | 4 区医学

小类 | 4 区工程：生物医学 4 区移植

最新[2025]版：

大类 | 3 区医学

小类 | 3 区工程：生物医学 3 区移植

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出版当年[2007]版：

Q3 ENGINEERING, BIOMEDICAL Q4 TRANSPLANTATION

最新[2023]版：

Q2 ENGINEERING, BIOMEDICAL Q2 TRANSPLANTATION

影响因子： 3.1 最新[2023版] 2.8 最新五年平均 1.45 出版当年[2007版] 1.281 出版当年五年平均 1.534 出版前一年[2006版] 1.631 出版后一年[2008版]

第一作者：

第一作者机构： [1]Department of Thoracic Cardiovascular Surgery, FuXing Hospital, Capital Medical University

通讯作者：

通讯机构： [*]Department of Vascular Surgery, XuanWu Hospital, Capital Medical University, No. 45 Changchun Street, Xuanwu District, Beijing 100053, People’s Republic of China

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