机构：[1]Xuanwu Hospital, Capital Medical University, Beijing 100053, China首都医科大学宣武医院[2]The International WIC Institute, Beijing University of Technology, Beijing 100124, China[3]Beijing Municipal Lab of Brain Informatics, Beijing 100124, China[4]Department of Life Science and Informatics, Maebashi Institute of Technology, Maebashi 371-0816, Japan
Previous studies of young people have revealed that the left dorsolateral prefrontal cortex (DLPFC) plays an important role in inductive reasoning. An fMRI experiment was performed in this study to examine whether the left DLPFC was involved in inductive reasoning of MCI patients and normal agings, and whether the activation pattern of this region was different between MCI patients and normal agings. The fMRI results indicated that MCI patients had no difference from normal agings in behavior performance (reaction time and accuracy) and the activation pattern of DLPFC. However, the BOLD response of the DLPFC region for MCI patients was weaker than that for normal agings, and the functional connectivity between the bilateral DLPFC regions for MCI patients was significantly higher than for normal agings. Taken together, these results indicated that DLPFC plays an important role in inductive reasoning of agings, and the functional abnormity of DLPFC may be an earlier marker of MCI before structural alterations.
基金：
National Natural Science Foundation of China (Grant No. 60775039), the Grant-in-aid for Scientific Research (Grant No. 18300053) from the Japanese Ministry of Education, Culture, Sports, Science and Technology,
and the outstanding doctor innovative foundation of Beijing University of Technology.
第一作者机构：[1]Xuanwu Hospital, Capital Medical University, Beijing 100053, China[3]Beijing Municipal Lab of Brain Informatics, Beijing 100124, China
通讯作者：
通讯机构：[1]Xuanwu Hospital, Capital Medical University, Beijing 100053, China[2]The International WIC Institute, Beijing University of Technology, Beijing 100124, China[3]Beijing Municipal Lab of Brain Informatics, Beijing 100124, China[4]Department of Life Science and Informatics, Maebashi Institute of Technology, Maebashi 371-0816, Japan
推荐引用方式(GB/T 7714)：
YANG YanHui,LIANG PeiPeng,LU ShengFu,et al.The role of the DLPFC in inductive reasoning of MCI patients and normal agings: An fMRI study[J].SCIENCE IN CHINA SERIES C-LIFE SCIENCES.2009,52(8):789-95.doi:10.1007/s11427-009-0089-1.
APA：
YANG YanHui,LIANG PeiPeng,LU ShengFu,LI KunCheng&ZHONG Ning.(2009).The role of the DLPFC in inductive reasoning of MCI patients and normal agings: An fMRI study.SCIENCE IN CHINA SERIES C-LIFE SCIENCES,52,(8)
MLA：
YANG YanHui,et al."The role of the DLPFC in inductive reasoning of MCI patients and normal agings: An fMRI study".SCIENCE IN CHINA SERIES C-LIFE SCIENCES 52..8(2009):789-95
