机构：[a]Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing 100053, China神经内科首都医科大学宣武医院[b]Department of Neurology, Shi Jing Shan Hospital, Beijing 100043, China
Increasing evidences suggest that polymorphisms within the promoter region of the vascular endothelial growth factor (VEGF) gene may elevate the risk for Alzheimer's disease (AD). In Northern Chinese Han, we found three polymorphisms in the VEGF promoter: -2578C/A (rs699947), -25491/D (rs35569394) and -1154G/A (rs1570360). A strong linkage disequilibrium was detected between -2578C/A and -25491/D. After adjusting the data by gender, age and the APOE epsilon 4 status using logistic regression, the -1154G/G genotype was found to increase the risk for sporadic AD (SAD) by 1.4-folds. In the subgroup of APOE epsilon 4 non-carriers, the -1154G allele and -2549D/-1154G haplotype were observed to be significantly higher in the 279 SAD patients than in the 317 healthy individuals. The present study provides the evidence that the -1154G allele and the -2549D/-1154G haplotype may be associated with the development of SAD in the individuals without APOE epsilon 4 allele. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
基金：
National Key Technology R&D Program in the Eleventh Five-year Plan Period (2006BAI02B01), the National Basic Research 973 Program (2006CB500700), National Natural Science Key Foundation (30830045),
Beijing Natural Sci ence Key Foundation (7071004), and Funding Project for Academic Human Resources Development in Institutions of Higher Learning Under the Jurisdiction of Beijing Municipality.
第一作者机构：[a]Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing 100053, China[b]Department of Neurology, Shi Jing Shan Hospital, Beijing 100043, China
通讯作者：
通讯机构：[a]Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Qian Yuan,Xiumei Zuo,Jianping Jia.Association between promoter polymorphisms of vascular endothelial growth factor gene and sporadic Alzheimer's disease among Northern Chinese Han[J].NEUROSCIENCE LETTERS.2009,457(3):133-136.doi:10.1016/j.neulet.2009.03.078.
APA：
Qian Yuan,Xiumei Zuo&Jianping Jia.(2009).Association between promoter polymorphisms of vascular endothelial growth factor gene and sporadic Alzheimer's disease among Northern Chinese Han.NEUROSCIENCE LETTERS,457,(3)
MLA：
Qian Yuan,et al."Association between promoter polymorphisms of vascular endothelial growth factor gene and sporadic Alzheimer's disease among Northern Chinese Han".NEUROSCIENCE LETTERS 457..3(2009):133-136
