机构：[a]Neurosurgery Department, Xuanwu hospital, Capital University of Medical Science, 45 Changchun Street, Beijing 100053, PR China神经外科首都医科大学宣武医院[b]Neurosurgery Department, 1st hospital, Jilin University, Changchun 130021, PR China
Gliomas are malignant primary brain tumors with high morbidity. This tumor has a feature of resistance to chemotherapy and radiotherapy and the underlying mechanism is not yet clear. Autophagy is an evolutionarily conserved process of cytoplasm and cellular organelle in lysosome degradation. Under poor conditions, cells use autophagy to recycle cellular components to sustain metabolism and to prevent the accumulation of damaged, toxic proteins and organelles. More and more recent experimental results suggest that autophagy allows tumor cells survive gene therapy, chemotherapy or nutrient deficient environment. Therefore, we propose the hypothesis that autophagy may be one of the factors influencing on malignant glioma's resistance to therapy. Although there is not yet reaching an agreement about the effects of autophagy on tumor cells survival and death and much more studies are needed to prove the effects of autophagy on malignant gliomas, it gives us a new direction to investigate the mechanism underlying therapy resistance of malignant gliomas. (C) 2009 Elsevier Ltd. All rights reserved.
基金：
National Nature and Science foundation of China (NSFC30500166), International Cooperation Grant (20070721) and Outstanding Youth Grant (20080139) from the science and technology department of Jilin Province.
第一作者机构：[a]Neurosurgery Department, Xuanwu hospital, Capital University of Medical Science, 45 Changchun Street, Beijing 100053, PR China
共同第一作者：
通讯作者：
通讯机构：[a]Neurosurgery Department, Xuanwu hospital, Capital University of Medical Science, 45 Changchun Street, Beijing 100053, PR China
推荐引用方式(GB/T 7714)：
Pengfei Ge,Yinan Luo,Shuanglin Fu,et al.Autophagy: A strategy for malignant gliomas' resistance to therapy[J].MEDICAL HYPOTHESES.2009,73(1):45-47.doi:10.1016/j.mehy.2008.11.047.
APA：
Pengfei Ge,Yinan Luo,Shuanglin Fu,Xunmin Ji&Feng Ling.(2009).Autophagy: A strategy for malignant gliomas' resistance to therapy.MEDICAL HYPOTHESES,73,(1)
MLA：
Pengfei Ge,et al."Autophagy: A strategy for malignant gliomas' resistance to therapy".MEDICAL HYPOTHESES 73..1(2009):45-47
