机构：[1]Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care,[2]Department of Neurological Surgery, University of California, San Francisco, California[3]Department of Neurology, University of California, San Francisco, California[4]Department of Surgery, University of California, San Francisco, California[5]Joint Graduate Program in Bioengineering, University of California, San Francisco/University of California, Berkeley, California[6]Department of Neurosurgery, XuanWu Hospital, Capital University of Medical Sciences, Beijing, China.神经外科首都医科大学宣武医院
Hemangiomas are angiogenesis-dependent benign vascular tumors that can rupture and cause intracranial hemorrhages. We previously showed that the transcription factor homeobox A5 (HoxA5), which is absent in activated angiogenic endothelial cells can block angiogenesis. Here, we investigated whether restoring expression of HoxA5 blocks hemangioma growth by transplanting mouse hemangioendothelioma endothelial cells (EOMA) or HoxA5-expressing EOMA cells into the brains of mice. The EOMA cells induced brain hemangiomas characterized by large cystlike spaces lined by thin walls of endothelial cells surrounded by scant smooth muscle cells. When HoxA5-expressing EOMA cells were injected, lesion volumes were reduced between 5- and 20-fold compared with the EOMA control group (p < 0.05). Restoration of HoxA5 was associated with increased thrombospondin-2, which inhibits angiogenesis and reduced hypoxia-inducible factor 1 alpha expression. These data suggest that restoring HoxA5 can attenuate experimental brain hemangioma development.
基金：
grants P01 NS44145, R01 NS27713 and R21 NS50668 from the National Institutes of Health.
第一作者机构：[1]Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care,[5]Joint Graduate Program in Bioengineering, University of California, San Francisco/University of California, Berkeley, California
共同第一作者：
通讯作者：
通讯机构：[*]Department of Anesthesia and Perioperative Care, University of California, San Francisco, 1001 Potrero Ave, Room 3C-38, San Francisco, CA 94110
推荐引用方式(GB/T 7714)：
Yiqian Zhu,Ileana C. Cuevas,Rodney Allanigue Gabriel,et al.Restoring Transcription Factor HoxA5 Expression Inhibits the Growth of Experimental Hemangiomas in the Brain[J].JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY.2009,68(6):626-632.doi:10.1097/NEN.0b013e3181a491ce.
APA：
Yiqian Zhu,Ileana C. Cuevas,Rodney Allanigue Gabriel,Hua Su,Stephen Nishimura...&Nancy J. Boudreau.(2009).Restoring Transcription Factor HoxA5 Expression Inhibits the Growth of Experimental Hemangiomas in the Brain.JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY,68,(6)
MLA：
Yiqian Zhu,et al."Restoring Transcription Factor HoxA5 Expression Inhibits the Growth of Experimental Hemangiomas in the Brain".JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 68..6(2009):626-632
