Elevated Plasma Surfactant Protein D (SP-D) Levels and a Direct Correlation with Anti-severe Acute Respiratory Syndrome Coronavirus-specific IgG Antibody in SARS Patients
机构：[1]Department of Basic Medicine, Taishan Medical University, Taian, China[2]Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands[3]The AIDS Research Center, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China[4]Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China[5]Department of Medicine, Xuanwu Hospital, Capital University of Medical Sciences, Beijing, China首都医科大学宣武医院[6]Department of Medicine, Taian Medical Center, Taian, Shandong, China[7]Medical Biotechnology Center, Institute of Medical Biology, University of Southern Denmark, Odense, Denmark[8]Medical Research Council Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford, UK
Pulmonary SP-D is a defence lectin promoting clearance of viral infections. SP-D is recognized to bind the S protein of SARS-CoV and enhance phagocytosis. Moreover, systemic SP-D is widely used as a biomarker of alveolar integrity. We investigated the relation between plasma SP-D, SARS-type pneumonia and the SARS-specific IgG response. Sixteen patients with SARS, 19 patients with community-acquired pneumonia (CAP) (Streptococcus pneumonia) and 16 healthy control subjects were enrolled in the study. Plasma SP-D and anti-SARS-CoV N protein IgG were measured using ELISA. SP-D was significantly elevated in SARS-type pneumonia [median (95% CI), 453 (379-963) ng/ml versus controls 218 (160-362) ng/ml, P < 0.05] like in patients with CAP. SP-D significantly correlated with anti-SARS-CoV N protein IgG (r(2) = 0.5995, P = 0.02). The possible re-emergence of SARS or SARS-like infections suggests a need for minimal traumatic techniques for following the alveolar compartment, e.g. during testing of antivirals. We suggest that monitoring systemic SP-D may be useful in monitoring the alveolar integrity in SARS-type pneumonia. The significant correlation between plasma SP-D and anti-SARS-CoV-specific antibodies support the role for SP-D in interlinking innate and adaptive immune pathways.
基金：
The Dutch Thrombosis Foundation, Natural Science Foundation of Shandong, National Natural Science Foundation of China,
the Danish Medical Research Council, the Novo-Nordic Foundation, The Lundbeck Foundation, Fonden til L?gevidenskabens Fremme,
the Danish Heart Foundation, The Benzon Foundation, The Augustinus Foundation and the Becket Foundation.
第一作者机构：[1]Department of Basic Medicine, Taishan Medical University, Taian, China[2]Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
共同第一作者：
通讯作者：
通讯机构：[*]Sorensen, Medical Biotechnology Center, Institute of Medical Biology, University of Southern Denmark, Winsloewparken 25.3, 5000 Odense-C, Denmark
推荐引用方式(GB/T 7714)：
Y. P. Wu,Z. H. Liu,R. Wei,et al.Elevated Plasma Surfactant Protein D (SP-D) Levels and a Direct Correlation with Anti-severe Acute Respiratory Syndrome Coronavirus-specific IgG Antibody in SARS Patients[J].SCANDINAVIAN JOURNAL OF IMMUNOLOGY.2009,69(6):508-515.doi:10.1111/j.1365-3083.2009.02245.x.
APA：
Y. P. Wu,Z. H. Liu,R. Wei,S. D. Pan,N. Y. Mao...&G. L. Sorensen.(2009).Elevated Plasma Surfactant Protein D (SP-D) Levels and a Direct Correlation with Anti-severe Acute Respiratory Syndrome Coronavirus-specific IgG Antibody in SARS Patients.SCANDINAVIAN JOURNAL OF IMMUNOLOGY,69,(6)
MLA：
Y. P. Wu,et al."Elevated Plasma Surfactant Protein D (SP-D) Levels and a Direct Correlation with Anti-severe Acute Respiratory Syndrome Coronavirus-specific IgG Antibody in SARS Patients".SCANDINAVIAN JOURNAL OF IMMUNOLOGY 69..6(2009):508-515
