机构：[1]Department of Neurobiology and Neurology, Key Laboratory of Neurodegenerative Diseases for Ministry of Education, Beijing Institute of Geriatrics and Xuanwu Hospital of Capital Medical University, #45 Changchun Street, Beijing 100053, China神经内科老年医学科神经变性病教育部重点实验室首都医科大学宣武医院
Depressive symptoms affect 40% to 50% of Parkinson's disease (PD) patients, and adversely impact their quality of life. The decrease of serotonin (5-HT) in the synaptic cleft is commonly considered as the cause of depression. The reuptake of 5-HT released into the synaptic cleft is mediated by the 5-HT transporter (5-HTT). Many studies have focused on the relationship between the 5-HTT-linked polymorphic region (5-HTTLPR) and depression. The present study is to investigate the association between the polymorphisms in the promoter of the 5-HTT gene (including 5-HTTLPR and rs25531), which determine either a higher or lower 5-HT uptake, and risk for depression of PD. Three hundred six idiopathic PD patients were recruited randomly from hospital clinic and the Center for Epidemiological Studies Depression Scale (CES-D) was used as the diagnosis or rating scale for depression. Polymerase Chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used and the patients' genotypes were divided as L-A, L-G, S-A, and S-G. We found no evidence for an association between variants of 5-HTTLPR and rs25531 alleles, and depressive symptoms in Chinese PD patients. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
基金：
Ministry of Sciences and Technology of China (2004BA702B02, 2006CB500701, 2006AA02A408, 2008ZX09312-014), and Beijing Natural Science Foundation (7031002).
第一作者机构：[1]Department of Neurobiology and Neurology, Key Laboratory of Neurodegenerative Diseases for Ministry of Education, Beijing Institute of Geriatrics and Xuanwu Hospital of Capital Medical University, #45 Changchun Street, Beijing 100053, China
通讯作者：
通讯机构：[1]Department of Neurobiology and Neurology, Key Laboratory of Neurodegenerative Diseases for Ministry of Education, Beijing Institute of Geriatrics and Xuanwu Hospital of Capital Medical University, #45 Changchun Street, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Jing-Lin Zhang,Jing-Fang Yang,Piu Chan.No association between polymorphism of serotonin transporter gene and depression in Parkinson's disease in Chinese[J].NEUROSCIENCE LETTERS.2009,455(3):155-158.doi:10.1016/j.neulet.2009.03.037.
APA：
Jing-Lin Zhang,Jing-Fang Yang&Piu Chan.(2009).No association between polymorphism of serotonin transporter gene and depression in Parkinson's disease in Chinese.NEUROSCIENCE LETTERS,455,(3)
MLA：
Jing-Lin Zhang,et al."No association between polymorphism of serotonin transporter gene and depression in Parkinson's disease in Chinese".NEUROSCIENCE LETTERS 455..3(2009):155-158
