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Prognostic Value of Tiam1 and Rac1 Overexpression in Nasopharyngeal Carcinoma

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WOS体系：
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收录情况： ◇ SCIE

作者：
Yan Qi [a] * ; Bo Huang [c] ; Linlin Yu [b] ; Qi Wang [d] ; Guiping Lan [c] ; Qiuhang Zhang [a,*] ;
机构： [a]Department of Otorhinolaryngology Head and Neck Surgery, XuanWu Hospital, Capital Medical University, [b]Department of Otorhinolaryngology Head and Neck Surgery, China Meitan General Hospital, Beijing , [c]Institute of Nasopharyngeal Carcinoma, People’s Hospital of Guangxi Zhuang Autonomous Region, [d]Guangxi Medical University, Nanning , China
出处：
DOI： 10.1159/000223440
ISSN：

关键词： Nasopharyngeal carcinoma Tiam1 Rac1 Invasion Metastasis Prognosis

摘要：
Purpose: This study is designed to investigate the roles of Tiam1 and Rac1 in nasopharyngeal carcinoma (NPC). Methods: NPC samples (n = 102) were analyzed with immunohistochemistry for Tiam1 and Rac1 proteins, 28 of which were also analyzed with quantitative RT-PCR and Western blots for Tiam1 and Rac1 mRNA and protein expression. The expression of Tiam1 and Rac1 in noncancerous nasopharyngeal tissue (n = 26) acted as a control. The expression was gauged regarding stage, grade and survival. Results: Tiam1 and Rac1 were overexpressed in NPC cells and their protein upregulation was significantly associated with stage and grading (p < 0.05 for all). Cox regression analysis revealed Tiam1 and Rac1 protein upregulation was correlated with lower disease-free and overall survival rates (p < 0.001). Conclusions: Upregulation of Tiam1 and Rac1 proteins may play a critical role in tumor progression of NPC, and work as a prognostic factor for NPC patients. Copyright (C) 2009 S. Karger AG, Basel

语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2008]版：
大类 | 4 区 医学
小类 | 4 区 耳鼻喉科学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 耳鼻喉科学
JCR分区：
出版当年[2007]版：
Q3 OTORHINOLARYNGOLOGY
最新[2023]版：
Q2 OTORHINOLARYNGOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2007版] 出版当年五年平均 出版前一年[2006版] 出版后一年[2008版]

第一作者：
第一作者机构： [a]Department of Otorhinolaryngology Head and Neck Surgery, XuanWu Hospital, Capital Medical University,
通讯作者：
通讯机构： [*]Otorhinolaryngology Head and Neck Surgery, XuanWu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053 (PR China)
推荐引用方式(GB/T 7714)：
Yan Qi,Bo Huang,Linlin Yu,et al.Prognostic Value of Tiam1 and Rac1 Overexpression in Nasopharyngeal Carcinoma[J].ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY.2009,71(3):163-171.doi:10.1159/000223440.
APA：
Yan Qi,Bo Huang,Linlin Yu,Qi Wang,Guiping Lan&Qiuhang Zhang.(2009).Prognostic Value of Tiam1 and Rac1 Overexpression in Nasopharyngeal Carcinoma.ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY,71,(3)
MLA：
Yan Qi,et al."Prognostic Value of Tiam1 and Rac1 Overexpression in Nasopharyngeal Carcinoma".ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY 71..3(2009):163-171

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