机构：[a]Center for Systems Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China[b]Department of General Surgery, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China普通外科首都医科大学宣武医院
Caveolin-1, a 21-24 kDa integral membrane protein, is a principal structural component of caveolae in vivo. To investigate the roles of caveolin-1, we established stable transfectants in Hs578T breast adenocarcinoma cells that had up- and down-regulated caveolin-1 expression. In the paper, we demonstrated that caveolin-1 overexpression in Hs578T cells significantly reduced staurosporine-induced apoptosis and the levels of caveolin-1 expression positively correlated with the number of colonies and colony size in soft agar. Our findings indicate for the first time in Hs578T cells that caveolin-1 might play a pivotal role in regulating apoptosis as a suppressor rather than a facilitator through inhibition of neutral-sphingomyelinase, decrease of ceramide, furthermore, activation of Akt signaling pathway. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
基金：
the Natural Science Foundation of China (30030186 and 30230120).
第一作者机构：[a]Center for Systems Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
共同第一作者：
通讯作者：
通讯机构：[a]Center for Systems Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
推荐引用方式(GB/T 7714)：
Ping Wu,Baoju Qi,Hua Zhu,et al.Suppression of staurosporine-mediated apoptosis in Hs578T breast cells through inhibition of neutral-sphingomyelinase by caveolin-1[J].CANCER LETTERS.2007,256(1):64-72.doi:10.1016/j.canlet.2007.05.007.
APA：
Ping Wu,Baoju Qi,Hua Zhu,Yamin Zheng,Fei Li&Jianwen Chen.(2007).Suppression of staurosporine-mediated apoptosis in Hs578T breast cells through inhibition of neutral-sphingomyelinase by caveolin-1.CANCER LETTERS,256,(1)
MLA：
Ping Wu,et al."Suppression of staurosporine-mediated apoptosis in Hs578T breast cells through inhibition of neutral-sphingomyelinase by caveolin-1".CANCER LETTERS 256..1(2007):64-72
医学