机构：[1]Department of Interventional Neuroradiology, Hopital Lariboisiere, AP-HP, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France[2]Department of Pathology, and Ear, Nose, Hopital Lariboisiere, AP-HP, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France[3]Throatand Maxillofacial Surgery, H?pital Lariboisiere, AP-HP, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France[4]Department of Neurosurgery and Neuroradiology, XuanWu Hospital of the Capital University of the Medical Science, Beijing, China神经外科放射科首都医科大学宣武医院
PURPOSE: To determine the location of calibrated tris-acryl gelatin microspheres (TGMs) in the arterial vasculature of nasopharyngeal angiofibromas (NAFs) and paragangliomas (PGs). MATERIALS AND METHODS: Forty-nine specimens (25 PGs and 24 NAFs) treated operatively after embolization with TGMs of various sizes (100-300 mu m to 900-1200 mu m) were stained with hematoxylin and eosin saffron and analyzed at an objective magnification of 10 or 20 with a micrometric eyepiece (magnification, X12.5). The diameter of occluded vessels, their localization (intra- or extratumoral), and the number and diameter of TGMs they contained were determined. RESULTS: Embolized vessels (N = 1125) were measured: 440 in PGs and 685 in NAFs. Vessels were 89% intratumoral and 11% extratumoral. The diameter of the occluded vessels increased significantly with the size range of TGMs used for embolization for each tumor type (P < .0001). Intratumoral occluded vessels were significantly smaller than extratumoral vessels (P < .0001). Distribution of TGMs within the vascular network (intratumoral or extratumoral location) were similar for NAFs and PGs. The intratumoral and extratumoral dissemination of TGMs was different when comparing 100-300-mu m TGMs versus 500-700-mu m TGMs (P = .0006) as well as 300-500-mu m TGMs versus 500-700-mu m TGMs (P = .0001). CONCLUSIONS: The size of the vessels occluded by TGMs and their intra- or extratumoral location directly depend on the size of the injected TGMs. The vessels located inside the tumors were smaller than those located outside the tumors. A threshold for the intratumoral penetration of TGMs in the vasculature can be proposed from these data. There was no evidence of different behavior of TGMs in NAFs versus PGs.
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外文
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出版当年[2004]版：
无
最新[2023]版：
大类|3 区医学
小类|3 区外周血管病3 区核医学
JCR分区：
出版当年[2003]版：
Q2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ2PERIPHERAL VASCULAR DISEASE
最新[2023]版：
Q2PERIPHERAL VASCULAR DISEASEQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者机构：[1]Department of Interventional Neuroradiology, Hopital Lariboisiere, AP-HP, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
通讯作者：
通讯机构：[1]Department of Interventional Neuroradiology, Hopital Lariboisiere, AP-HP, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
推荐引用方式(GB/T 7714)：
Alexandre Laurent,Michel Wassef,Rene Chapot,et al.Partition of calibrated tris-acryl gelatin microspheres in the arterial vasculature of embolized nasopharyngeal angiofibromas and paragangliomas[J].JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY.2005,16(4):507-513.doi:10.1097/01.RVI.0000150038.99488.01.
APA：
Alexandre Laurent,Michel Wassef,Rene Chapot,Yabing Wang,Emmanuel Houdart...&Jean-Jacques Merland.(2005).Partition of calibrated tris-acryl gelatin microspheres in the arterial vasculature of embolized nasopharyngeal angiofibromas and paragangliomas.JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY,16,(4)
MLA：
Alexandre Laurent,et al."Partition of calibrated tris-acryl gelatin microspheres in the arterial vasculature of embolized nasopharyngeal angiofibromas and paragangliomas".JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY 16..4(2005):507-513
