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Epigallocatechin-3-gallate stimulates autophagy and reduces apoptosis levels in retinal Müller cells under high-glucose conditions

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收录情况： ◇ SCIE

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机构： [a]The Second Affiliated Hospital of Soochow University. Suzhou, 215004, China [b]Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, 215021, China [c]Shanghai Key Laboratory of Fundus Disease, Shanghai, 200080, China [d]Department of Ophthalmology, Shanghai First People's Hospital, School of Medicine, Shanghai JiaoTong University, 100 Haining Road, Shanghai, 200080, China

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关键词： Apoptosis Autophagy Diabetes retinopathy EGCG Müller cells

摘要：

Retinal neurodegeneration is an early feature in the pathogenesis of diabetic retinopathy (DR). Autophagy is an intracellular catabolic process involved in protein and organelle degradation that has been linked in DR. Epigallocatechin gallate (EGCG) is a major polyphenol in green tea that has beneficial effects in diabetic. however, it is not currently known whether EGCG can regulate Müller cell autophagy. Here, we showed that EGCG increased autophagy by promoting the formation of autophagosomes, increasing lysosomal acidification, and stimulating autophagic flux in Müller cells, while high glucose (HG) induced a decrease in autophagy and an increase in apoptosis. However, retinal Müller cells in HG treated with EGCG showed autophagy machinery activation and reestablishment of cargo degradation, protecting the cells from apoptosis. EGCG could increase the ability of cells to proliferate by increasing autophagy. In an experimental model of diabetic retinopathy, EGCG reduced the reactive gliosis of Müller cells and decreased retinal damage. These results highlight that HG downregulates autophagy and accumulates P62 cargo due to lysosomal dysfunction and then increases apoptosis, which was reversed by treatment with EGCG. This finding might be valuable for developing a novel therapeutic strategy to treat DR. © 2019 Elsevier Inc.

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出版当年[2018]版：

大类 | 2 区医学

小类 | 3 区细胞生物学 3 区肿瘤学

最新[2023]版：

大类 | 3 区生物学

小类 | 4 区细胞生物学 4 区肿瘤学

JCR分区：

出版当年[2017]版：

Q2 ONCOLOGY Q3 CELL BIOLOGY

最新[2023]版：

Q2 ONCOLOGY Q3 CELL BIOLOGY

影响因子： 3.3 最新[2023版] 3.3 最新五年平均 3.309 出版当年[2017版] 3.274 出版当年五年平均 3.546 出版前一年[2016版] 3.329 出版后一年[2018版]

第一作者：

第一作者机构： [a]The Second Affiliated Hospital of Soochow University. Suzhou, 215004, China [b]Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, 215021, China

通讯作者：

通讯机构： [*1]Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Ganjiang East Road 200, Suzhou, 215021, China. [*2]Shanghai Key Laboratory of Fundus Disease, Shanghai, China.

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