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Murine B7-H3 is a co-stimulatory molecule for T cell activation

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机构： [1]Department of Clinical Laboratory,The Second Affiliated Hospital of Soochow University, Suzhou, China. [2]Department of Medical Equipment, The Second Affiliated Hospital of Soochow University, Suzhou, China. [3]Institute of Medical Biotechnology, Soochow University, Suzhou, China.

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The B7 family member B7-H3 (CD276) plays a key role during an immune response but its function remains controversial. In this study, we found that murine B7-H3 up-regulated the proliferation and cytokine production of T cells. Our study suggested that there was no interaction of murine B7-H3 with a triggering receptor expressed on myeloid cells (TREM)-like transcript 2 (TLT-2). Further studies demonstrated that mouse B7-H3 specifically bound to T cells and its receptor was not murine TLT-2. Moreover, murine B7-H3 was a positive co-stimulatory molecule in the regulation of T cell-mediated immune responses. © 2013 Mary Ann Liebert, Inc.

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第一作者机构： [1]Department of Clinical Laboratory,The Second Affiliated Hospital of Soochow University, Suzhou, China.

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通讯机构： [*]Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Sanxiang Road, No.1055 Suzhou, 215004 China

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