机构：[1]Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, 215004, China
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摘要：
Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that regulates many important biological processes. It deacetylates alpha-tubulin, Hsp90 and cortactin, and forms complexes with other partner proteins. When the misfolded proteins are too more to be degradated by the chaperone refolding system and the ubiquitin-proteasome system in cultured cells, misfolded proteins are specifically transported to a cytoplasmic juxtanuclear structure called aggresome by HDAC6, facilitating their clearance by autophagy. The diverse functions of HDAC6 in misfolded proteins degradation pathway suggest that it is a potential therapeutic target for the treatment of "conformational diseases".
语种：
中文
PubmedID：
第一作者：
第一作者机构：[1]Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, 215004, China
推荐引用方式(GB/T 7714)：
Su M,Sun X,Liu C.F.[Histone deacetylase 6: the key regulator of misfolded proteins].[J].Sheng li ke xue jin zhan [Progress in physiology].2010,41(2):112-6.
