Abnormal Spontaneous Neuronal Discharge and Local Field Potential both in Cortex and Striatum of a Non- human Primate of Parkinson's Disease using Implantable Microelectrode Arrays
机构：[a]State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, China[b]University of Chinese Academy of Sciences, Beijing 100190, China[c]Wincon TheraCells Biotechnologies Co., Ltd., Nanning 530002, China[d]Department of Neurobiology, Xuanwu Hospital, Capital Medical University, The Beijing Key Laboratory of Parkinson's Disease, Beijing 100053, China首都医科大学宣武医院
Parkinson's disease (PD) is a neurodegenerative disease with the loss of dopaminergic neurons in substantia nigra. This study described abnormal spontaneous neuronal information both in cortex and striatum of a non-human primate of PD using implantable microelectrode arrays. In cortex of PD monkey, Neurons discharged from single-spike mode to burst-firing mode compared to normal monkey; Mean amplitude was 197 μV that was twice of mean amplitude of normal monkey, and mean firing rate was 82Hz; burst-firing activity showed distinctive, stereotypic periods of oscillatory lasted for 20 ± 5s occurring ever 30-40 seconds, which was consistent with local field potential (LFP) oscillating at 4.79Hz related to PD tremor; neuronal discharge were approximately synchronous from four channels, that were consistent with local field potential fluctuating greatly with a correlation coefficient of 0.99997, and the main frequency of local field potential had a good respond to firing rate of spike with a correlation coefficient of 0.9891. In striatum of PD monkey, two types of neurons were detected with mean amplitude of 102 μV and 296 μV respectively; the mean firing rate was 62 Hz significantly higher than that in normal monkey; as for one representative type of neurons, with respect to local field potential oscillating at a period in cortex, local field potential continuously oscillated in striatum at low frequency at the range of 4-7Hz which was constituent with neuronal burst firing rate, while single neuron discharged at the range of 10-32Hz, almost at beta frequencies. Abnormal neural information detection by microelectrode arrays with ifferent signals in different position will play an important role in target location in brain of PD patients, especially for treatment. ? 2018 IEEE.
基金：
Research sponsored by the NSFC (No.61527815, No.31500800,
No.61501426, No.61601435), the National Key Research and Development
Program of China (2017YFA0205902), Frontier Science Key Research
Project and Strategic Priority Research Program of the Chinese Academy of
Sciences (QYZDJ-SSW-SYS015, XDA16020902), and the Beijing Science
and Technology Plan(Z161100004916001).
语种：
外文
第一作者：
第一作者机构：[a]State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, China[b]University of Chinese Academy of Sciences, Beijing 100190, China
通讯作者：
通讯机构：[a]State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, China[b]University of Chinese Academy of Sciences, Beijing 100190, China
推荐引用方式(GB/T 7714)：
Mixia Wang,Yilin Song,Song Zhang,et al.Abnormal Spontaneous Neuronal Discharge and Local Field Potential both in Cortex and Striatum of a Non- human Primate of Parkinson's Disease using Implantable Microelectrode Arrays[J].Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS.2018,2018-July:doi:10.1109/EMBC.2018.8512999.
APA：
Mixia Wang,Yilin Song,Song Zhang,Shengwei Xu,Guihua Xiao...&Xinxia Cai.(2018).Abnormal Spontaneous Neuronal Discharge and Local Field Potential both in Cortex and Striatum of a Non- human Primate of Parkinson's Disease using Implantable Microelectrode Arrays.Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS,2018-July,
MLA：
Mixia Wang,et al."Abnormal Spontaneous Neuronal Discharge and Local Field Potential both in Cortex and Striatum of a Non- human Primate of Parkinson's Disease using Implantable Microelectrode Arrays".Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2018-July.(2018)
