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Temperatures Achieved in Human and Canine Neocortex During Intraoperative Passive or Active Focal Cooling

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机构： [1]Department of Neurosurgery, Washington University School of Medicine, St. Louis, Missouri. [2]Department of Clinical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota. [3]Department of Pediatrics (Clinical Neuroscience), University of Minnesota, Minneapolis, Minnesota. [4]Department of Neurological Surgery, University of Washington, Seattle, Washington. [5]Department of Neurology and Regional Epilepsy Center, University of Washington, Seattle, Washington. [6]Mercy Clinic Child Neurology, St. Louis, Missouri. [7]Center for Human Development and Disability, University of Washington, Seattle, Washington [8]Electrophysiology Laboratory, Xuanwu Hospital Capital Medical University, Beijing, China, and Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing, China

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Focal cortical cooling inhibits seizures and prevents acquired epileptogenesis in rodents. To investigate the potential clinical utility of this treatment modality, we examined the thermal characteristics of canine and human brain undergoing active and passive surface cooling in intraoperative settings. Four patients with intractable epilepsy were treated in a standard manner. Before the resection of a neocortical epileptogenic focus, multiple intraoperative studies of active (custom-made cooled irrigation-perfused grid) and passive (stainless steel probe) cooling were performed. We also actively cooled the neocortices of two dogs with perfused grids implanted for 2 hours. Focal surface cooling of the human brain causes predictable depth-dependent cooling of the underlying brain tissue. Cooling of 0.6-2°C was achieved both actively and passively to a depth of 10-15 mm from the cortical surface. The perfused grid permitted comparable and persistent cooling of canine neocortex when the craniotomy was closed. Thus, the human cortex can easily be cooled with the use of simple devices such as a cooling grid or a small passive probe. These techniques provide pilot data for the design of a permanently implantable device to control intractable epilepsy. © Copyright 2015, Mary Ann Liebert, Inc.

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大类 | 4 区医学

小类 | 4 区危重病医学

第一作者：

第一作者机构： [1]Department of Neurosurgery, Washington University School of Medicine, St. Louis, Missouri. [*]Department of Neurosurgery Washington University School of Medicine One Children’s Place, Suite 4s20 St. Louis, MO 63110

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通讯机构： [*]Department of Neurosurgery Washington University School of Medicine One Children’s Place, Suite 4s20 St. Louis, MO 63110

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