机构：[1]Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, New York, USA.[2]Departments of Neurology and Pathology, Columbia University, New York, New York, USA.[3]Bedford Veterans Administration Medical Center, Bedford, Massachusetts, USA.[4]Department of Neurology, Xuan-Wu Hospital, Beijing, China.神经内科首都医科大学宣武医院
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal features of the disease: an age-dependent and levodopa-responsive slowness of movement associated with diminished dopamine release and axonal pathology of nigrostriatal dopaminergic projection. These mice provide a valid model of Parkinson's disease and are a resource for the investigation of pathogenesis and therapeutics. ? 2009 Nature America, Inc. All rights reserved.
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外文
中科院(CAS)分区：
出版当年[2008]版：
大类|1 区医学
小类|1 区神经科学
最新[2023]版：
大类|1 区医学
小类|1 区神经科学
第一作者：
第一作者机构：[1]Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, New York, USA.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, New York, USA.
推荐引用方式(GB/T 7714)：
Yanping Li,Wencheng Liu,Tinmarla F Oo,et al.Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson’s disease[J].Nature Neuroscience.2009,12(7):doi:10.1038/nn.2349.
APA：
Yanping Li,Wencheng Liu,Tinmarla F Oo,Lei Wang,Yi Tang...&Chenjian Li.(2009).Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson’s disease.Nature Neuroscience,12,(7)
MLA：
Yanping Li,et al."Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson’s disease".Nature Neuroscience 12..7(2009)
医学