Objective: To investigate the relationship between severity of cerebrovascular atherosclerosis stenosis and that of coronary atherosclerosis stenosis. Methods: Cerebral angiography and coronary angiography were performed in 34 patients who had coronary disease with cerebral ischemia. Patients were divided into 3 subgroups according to the degree of stenosis on angiography, concomitant diseases, risk factors and biochemical data. Results: The follow-up study showed that the incidence of cardiac and cerebrovascular death increased significantly in patients with moderate to severe stenosis of coronary and cerebral arteries; the severity of stenosis in the coronary artery parallels that in the solitary carotid artery, or dual carotid and vertebral arteries. Conclusions: Patients with coronary and cerebral artery stenosis, especially those with multi-risk factors, such as hypertension, diabetes and cigarette smoking, should receive intensive treatment to reduce cardiac and cerebrovascular events.