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Resistance to the induction of mixed chimerism in spontaneously diabetic NOD mice depends on the CD40/CD154 pathway and donor MHC disparity

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机构： [a]Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, Minnesota, USA [b]Department of General Surgery, Xuan Wu Hospital, Capital Medical University, Beijing, China [c]Department of Surgery, First Hospital, Beijing University, Beijing, China [d]Division of Transplantation, Department of General Surgery, Baskent University Faculty of Medicine, Ankara, Turkey

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关键词： Bone marrow transplantation CD154 Mixed chimerism NOD mice Type 1 diabetes

摘要：

Blockade of CD40/CD154 pathway has proven effective in promoting the induction of allogeneic mixed chimerism. Using NOD mouse model of human type 1 diabetes, we investigated whether allogeneic mixed chimerism can be induced in prediabetic NOD mice and in spontaneously diabetic NOD mice under nonmyeloablative and irradiation-free conditioning therapy and anti-CD154 mAb as a shortterm posttransplant treatment. We found that spontaneously diabetic NOD mice are more resistant to the induction of allogeneic mixed chimerism than prediabetic NOD mice under our nonmyeloablative and irradiation-free conditioning therapy. This alloresistance in spontaneously diabetic NOD mice is dependent on the CD40/CD154 pathway and donor MHC disparity. © 2007 New York Academy of Sciences.

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出版当年[2006]版：

大类 | 3 区综合性期刊

最新[2023]版：

大类 | 3 区综合性期刊

小类 | 3 区综合性期刊

第一作者：

第一作者机构： [a]Department of Surgery, Diabetes Institute for Immunology and Transplantation, University of Minnesota, Minneapolis, Minnesota, USA [b]Department of General Surgery, Xuan Wu Hospital, Capital Medical University, Beijing, China

通讯作者：

通讯机构： [*1]Department of Surgery, MMC 195, University of Minnesota, 420 Delaware Street S.E., Minneapolis, MN 55455

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