机构：[1]Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049[2]PLA Information Engineering University, Zhengzhou Henan 450002[3]Department of Radiology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053放射科首都医科大学宣武医院[4]Neurobiology Center, Xuzhou Medical College, Xuzhou Jiangsu 221002[5]Department of Physics , Zhejiang University, Hangzhou Zhejiang 310027
To explore the gray matter loss of Alzheimer's disease (AD) patients by processing the magnetic resonance imaging (MRI) with computer, a voxel-based morphometry (VBM) method was applied in this study. Bilateral loss of gray matter in AD patients was found in the entorhinal/hippocampal/parahippocampal cortex areas, amygdala, the head of the caudate nucleus, middle temporal gyrus, cingulate gyrus, inferior parietal lobule, insula and dorso-lateral prefrontal cortex. Furthermore, area of right pulvinar, cortex of superior temporal gyrus and superior parietal lobule reduced significantly. On the other hand, somatosensory/motor cortex, cerebellum and occipital lobe were relatively intact. VBM overcomes the shortcomings of region of interesting (ROI), such as time-consuming, dependence on observer, and poorly reproducible, and can analyze the gray matter loss objectively and automatically and have a good perspective for clinical applications.
基金：
the National Natural Science Foundation of China(90209030)
语种：
外文
第一作者：
第一作者机构：[1]Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049[2]PLA Information Engineering University, Zhengzhou Henan 450002
通讯作者：
通讯机构：[1]Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049
推荐引用方式(GB/T 7714)：
YAN Bin,WANG Wei,LIU Hua,et al.Study of gray matter loss in alzheimer's disease based on automatic voxel-based morphometry[J].Hangtian Yixue Yu Yixue Gongcheng/Space Medicine and Medical Engineering.2006,19(1):
APA：
YAN Bin,WANG Wei,LIU Hua,LI Kun-cheng,LI Ke...&TANG Xiao-wei.(2006).Study of gray matter loss in alzheimer's disease based on automatic voxel-based morphometry.Hangtian Yixue Yu Yixue Gongcheng/Space Medicine and Medical Engineering,19,(1)
MLA：
YAN Bin,et al."Study of gray matter loss in alzheimer's disease based on automatic voxel-based morphometry".Hangtian Yixue Yu Yixue Gongcheng/Space Medicine and Medical Engineering 19..1(2006)
