机构：[a]Department of Neural Plasticity, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa,Setagaya-ku, Tokyo 156-8585, Japan[b]Sino-Japan Joint Laboratory on Neurodegenerative Diseases, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, China老年医学科首都医科大学宣武医院
α-Synuclein is a neuronal protein originally identified in Alzheimer's disease (AD) amyloid plaques in 1993 and named non-Aβ component precursor (NACP) [92]. Later, the discovery of two missense mutations (G88C and G209A), which resulted in Ala30Pro (A30P) and Ala53Thr (A53T) substitutions, of the α-synuclein gene in certain autosomal-dominant early onset familial Parkinson's disease (PD) has greatly promoted the understanding of the role of α-synuclein in the pathogenesis of neurodegenerative diseases, such as PD, dementia with Lewy bodies (DLB) and multiple system atrophy (MSA) [5,6,51, 75]. At present, it is widely accepted that α-synuclein may play a central role in several neurodegenerative disorders because of the presence of insoluble α-synuclein as the major fibrillar component of inclusion bodies. From the cloning of the human α-synuclein cDNA in 1993 to the present, α-synuclein has been carefully documented in many aspects. In this article, we review the progress of studies on α-synuclein and its role in α-synuclein-related neurodegenerative diseases.
第一作者机构：[a]Department of Neural Plasticity, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa,Setagaya-ku, Tokyo 156-8585, Japan[b]Sino-Japan Joint Laboratory on Neurodegenerative Diseases, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, China
通讯作者：
通讯机构：[a]Department of Neural Plasticity, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa,Setagaya-ku, Tokyo 156-8585, Japan
推荐引用方式(GB/T 7714)：
Qiu-Lan Ma,Piu Chan,Mitsunobu Yoshii,et al.α-synuclein aggregation and neurodegenerative diseases[J].JOURNAL OF ALZHEIMERS DISEASE.2003,5(2):139-148.doi:10.3233/JAD-2003-5208.
APA：
Qiu-Lan Ma,Piu Chan,Mitsunobu Yoshii&Kenji U′eda.(2003).α-synuclein aggregation and neurodegenerative diseases.JOURNAL OF ALZHEIMERS DISEASE,5,(2)
MLA：
Qiu-Lan Ma,et al."α-synuclein aggregation and neurodegenerative diseases".JOURNAL OF ALZHEIMERS DISEASE 5..2(2003):139-148
