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Quantitative assessment of the intracranial vasculature in an older adult population using iCafe

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机构: [a]Department of Electrical Engineering, University of Washington, Seattle, WA, USA [b]Department of Radiology, University of Washington, Seattle, WA, USA [c]Department of Neurology, Xuanwu hospital, Capital Medical University, Beijing, China [d]Wellesley College, Wellesley, MA, USA [e]Biomedical Engineering, Tsinghua University, Beijing, China [f]Department of Surgery, University of Washington, Seattle, WA, USA
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关键词: Aging Feature extraction iCafe Intracranial artery Vascular biomarker Vascular change

摘要:
Comprehensive quantification of intracranial artery features may help us assess and understand variations of blood supply during brain development and aging. We analyzed vasculature features of 163 participants (age 56–85 years, mean of 71) from a community study to investigate if any of the features varied with age. Three-dimensional time-of-flight magnetic resonance angiography images of these participants were processed in IntraCranial artery feature extraction technique (a recently developed technique to obtain quantitative features of arteries) to divide intracranial vasculatures into anatomical segments and generate 8 morphometry and intensity features for each segment. Overall, increase in age was found negatively associated with number of branches and average order of intracranial arteries while positively associated with tortuosity, which remained after adjusting for cardiovascular risk factors. The associations with number of branches and average order were consistently found between 3 main intracranial artery regions, whereas the association with tortuosity appeared to be present only in middle cerebral artery/distal arteries. The combination of time-of-flight magnetic resonance angiography and IntraCranial artery feature extraction technique may provide an effective way to study vascular conditions and changes in the aging brain. © 2019 Elsevier Inc.

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出版当年[2018]版:
大类 | 2 区 医学
小类 | 2 区 老年医学 2 区 神经科学
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 老年医学 3 区 神经科学
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出版当年[2017]版:
Q1 GERIATRICS & GERONTOLOGY Q1 NEUROSCIENCES
最新[2023]版:
Q2 GERIATRICS & GERONTOLOGY Q2 NEUROSCIENCES

影响因子: 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

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第一作者机构: [a]Department of Electrical Engineering, University of Washington, Seattle, WA, USA
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通讯机构: [*1]Department of Radiology, University of Washington, Box 358050 850 Republican St, Rm 127, Seattle, WA, 98109-4714. [b]Department of Radiology, University of Washington, Seattle, WA, USA
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