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In Vitro Activity of Ceftazidime-Avibactam against Carbapenem-Resistant and Hypervirulent Klebsiella pneumoniae Isolates.

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机构: [a]Department of Clinical Laboratory, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China [b]Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China [c]Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China [d]Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China [e]Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA [f]Case VA Center for Antimicrobial Resistance and Epidemiology (CARES), Case Western Reserve University, Cleveland, Ohio, USA [g]Research Service, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA [h]Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA [i]Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA [j]Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York, USA [k]Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA [l]Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA
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Carbapenem-resistant and hypervirulent Klebsiella pneumoniae (CR-hvKp) strains have emerged while antimicrobial treatment options remain limited. Herein, we tested the in vitro activity of ceftazidime-avibactam and other comparator antibiotics against 65 CR-hvKp isolates. Ceftazidime-avibactam, colistin, and tigecycline are highly active in vitro against CR-hvKp isolates (MIC90, ≤1 μg/ml), including K. pneumoniae carbapenemase 2 (KPC-2)-producing ST11 CR-hvKp. On the basis of previous clinical experience and the in vitro data presented herein, we posit that ceftazidime-avibactam is a therapeutic option against CR-hvKp infections. Copyright © 2018 American Society for Microbiology.

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出版当年[2017]版:
大类 | 2 区 医学
小类 | 2 区 微生物学 2 区 药学
最新[2025]版:
大类 | 2 区 医学
小类 | 2 区 微生物学 2 区 药学
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第一作者机构: [a]Department of Clinical Laboratory, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China [b]Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
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通讯机构: [i]Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA
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