机构：[1]Department of Ultrasound, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P.R. China[2]Department of Medical Ultrasound, Nanjing Medical University Affiliated Wuxi People’s Hospital, Wuxi, Jiangsu, P.R. China
BACKGROUND Tumor volume doubling time (TVDT) is relatively important for breast cancer diagnosis and prognosis evaluation. This study aimed to analyze the related factors that may affect the TVDT of breast cancer by three-dimensional ultrasound (3D-US). MATERIAL AND METHODS A total of 69 breast cancer patients were selected. 3D-US was applied to measure the volume of breast lumps diagnosed as BI-RADS-US 4A by conventional ultrasound. TVDT was calculated according to the formula TVDT=DT×log2/log(V2/V1). Multiple linear regression analysis was performed to analyze the factors influencing breast cancer TVDT. RESULTS The mean and median TVDT were 185±126 (range 66-521) and 164 days, respectively. TVDT showed no statistical significance according to regular shape, coarse margin, spicule sign, peripheral hyperechoic halo, microcalcification, and different posterior echo characteristics (P>0.05). Patients grouped by age, axillary lymphatic metastasis, histological differentiation, and Nottingham prognostic index (NPI) score exhibited significantly different TVDT (P<0.05). On the contrary, patients with different menstrual conditions, breast cancer family history, or pathological types presented similar TVDT (P>0.05). TVDT was obviously different in breast cancer with different ER, PR, Ki-67, and molecular subtyping but not HER2 expression. Multivariate analysis revealed that NPI score, axillary lymphatic metastasis, Ki-67, and molecular subtyping were risk factors of TVDT in breast cancer (P<0.05). CONCLUSIONS Breast cancer TVDT was significantly correlated with NPI score, axillary lymphatic metastasis, Ki-67, and molecular subtyping. Triple-negative breast cancer exhibited the most rapid growth.
基金：
This study was supported by the Research Project for the Women’s and Children’s Health of Jiangsu Province National Health
and Family Planning Commission (F201567), the Key Research Project of Medical Research in Wuxi Hospital Management Center
(YGZXZ1509), and the Research Project for Women’s and Children’s Health of the Wuxi National Health and Family Planning
Commission (FYKY201502)
第一作者机构：[1]Department of Ultrasound, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P.R. China
通讯作者：
通讯机构：[2]Department of Medical Ultrasound, Nanjing Medical University Affiliated Wuxi People’s Hospital, Wuxi, Jiangsu, P.R. China
推荐引用方式(GB/T 7714)：
Shuying Zhang,Yan Ding,Qiaoying Zhu,et al.Correlation Factors Analysis of Breast Cancer Tumor Volume Doubling Time Measured by 3D-Ultrasound.[J].MEDICAL SCIENCE MONITOR.2017,23:3147-3153.
APA：
Shuying Zhang,Yan Ding,Qiaoying Zhu,Cheng Wang,Pengxi Wu&Ji Dong.(2017).Correlation Factors Analysis of Breast Cancer Tumor Volume Doubling Time Measured by 3D-Ultrasound..MEDICAL SCIENCE MONITOR,23,
MLA：
Shuying Zhang,et al."Correlation Factors Analysis of Breast Cancer Tumor Volume Doubling Time Measured by 3D-Ultrasound.".MEDICAL SCIENCE MONITOR 23.(2017):3147-3153
