机构：[1]Department of General Surgery, the Second Affiliated Hospital of Soochow University, Suzhou, China[2]Department of Pathology and Wuxi Oncology Institute, the Affiliated Hospital of Jiangnan University, Wuxi, China[3]Department of Oncology, the First Affiliated Hospital of Soochow University, Suzhou, China
出处：
ISSN：
摘要：
CXCL13 plays a unique role in the trafficking and homing of B1 cells associated with its cognate receptor, CXCR5. The CXCR5-CXCL13 axis has been previously demonstrated to be a poor prognosis factor in malignancies. However, the clinical significance of the CXCR5-CXCL13 expression in colorectal cancer carcinoma (CRC) remains unclear. The aim of this study was to investigate the CXCR5-CXCL13 expression in CRC and determine its correlation with the progression and prognosis of the tumor.
A total of 144 paraffin-embedded specimens with advanced colon cancer were assessed for CXCR5 and CXCL13 by immunohistochemistry. Patients' long-term survival was also monitored. There were significant differences in lymph node metastasis (p = 0.0066), neural invasion (p = 0.0061) and neural invasion (p = 0.0001) between high and low expression of CXCR5.
There were significant differences in distant metastasis (p = 0.0261), TNM stage (p = 0.0409), differentiation (p < 0.0001) and neural invasion of the CXCL13. Both CXCR5 and CXCL13 was associated with poor correlation with the overall survival (OS) and relapse-free survival (RFS).
Our data suggest that the CXCR5 and CXCL13 may play a crucial role in the development, metastasis and relapse of advanced colon cancer. They can be used as prognostic markers of colon cancer in clinical practice.
基金：
Foundation of Wuxi Hospital management center (Nos.
CSEY1N1106), National Natural Science Foundation of
China (Nos. 81301784)
第一作者机构：[1]Department of General Surgery, the Second Affiliated Hospital of Soochow University, Suzhou, China[2]Department of Pathology and Wuxi Oncology Institute, the Affiliated Hospital of Jiangnan University, Wuxi, China
通讯作者：
通讯机构：[1]Department of General Surgery, the Second Affiliated Hospital of Soochow University, Suzhou, China
推荐引用方式(GB/T 7714)：
X.-W. QI,S.-H. XIA,Y. YIN,et al.Expression features of CXCR5 and its ligand, CXCL13 associated with poor prognosis of advanced colorectal cancer.[J].European review for medical and pharmacological sciences.2014,18(13):1916-24.
APA：
X.-W. QI,S.-H. XIA,Y. YIN,L.-F. JIN,Y. PU...&H.-R. WU.(2014).Expression features of CXCR5 and its ligand, CXCL13 associated with poor prognosis of advanced colorectal cancer..European review for medical and pharmacological sciences,18,(13)
MLA：
X.-W. QI,et al."Expression features of CXCR5 and its ligand, CXCL13 associated with poor prognosis of advanced colorectal cancer.".European review for medical and pharmacological sciences 18..13(2014):1916-24
